烧伤涂膜剂质量标准研究  

Quality Criteria of Burn Membrane

作　　者：张秋红[1] 李德平[1] 张忠义[1] 

机构地区：[1]南京军区南京总医院制剂科南方医科大学南京临床学院,江苏南京210002

出　　处：《中国药业》2006年第14期10-11,共2页China Pharmaceuticals

摘　　要：目的建立烧伤涂膜剂的质量控制方法。方法用薄层色谱法(TLC法)鉴定涂膜剂中的虎杖、黄芩,用高效液相色谱法(H PLC法)测定虎杖中大黄素含量。结果TLC法鉴定结果满意;回归方程为A=3.18×107C+2.03×105(r=0.9997),大黄素浓度在0.1～0.5m g m/L范围内与峰面积线性关系良好,平均加样回收率为98.67%(n=6)。结论该法操作简便,结果可靠,重现性好,可作为烧伤涂膜剂的质量控制方法。Objective To establish the quality criteria of bum membrane. Methods TLC method was applicated to determine and differentiate the Rhizoma polygoni cuspiditi and Radix scutellariae. HPLC method was used for detecting the content of emodin in bum membrane. Results The components were determined well. The regression equation by HPLC was A = 3.18 ×10^7 C ＋ 2. 03 ×10^5（ r = 0. 999 7）. Curcumin had good linear relation within the range of 0. 1 -0. 5 mg/mL. The average recovery rate was 98.67% （n =6）. Conclusion This method is convenient, accurate and sensitive. It can be used as quality control of bum membrane.

关 键 词：烧伤涂膜剂 薄层色谱法 大黄素 高效液相色谱法 含量测定 

分 类 号：R286.0[医药卫生—中药学] R284.1[医药卫生—中医学]