门冬胰岛素30与盐酸吡格列酮联合治疗对2型糖尿病患者血糖的影响  

Effects of combination of insulin Aspart 30 and pioglitazone hydrochloride on blood glucose in type 2 diabetes mellitus patients

作　　者：董健[1] 代芳[2] 王亚林[1] 于瑞萍[1] 刘波[1] 

机构地区：[1]贵州省人民医院内分泌科,贵阳550002 [2]贵阳中医学院附一院内分泌科,贵阳550001

出　　处：《郑州大学学报（医学版）》2006年第5期936-938,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:观察门冬胰岛素30(诺和锐30)和盐酸吡格列酮(瑞彤)联合治疗对2型糖尿病(T2DM)患者血糖的影响。方法:选择60例经诺和锐30强化血糖控制达标2周后患者,随机分为诺和锐30联合瑞彤观察组29例和诺和锐30单用对照组31例,比较2组各时段血糖水平、糖化血红蛋白(HbA1C)含量和24h胰岛素用量。结果:与对照组比较,观察组在早餐前和三餐后30min、60min、120min血糖下降(P<0.05或0.01),HbA1C下降(P=0.042);且24h胰岛素用量减少(P<0.0001)。结论:T2DM患者早期联合噻唑烷二酮类胰岛素增敏剂治疗,可降低胰岛素抵抗,改善血糖控制。Aim： To investigate the blood glucose changes in patients with type 2 diabetes mellitus （T2DM） after the treatment with Insulin Aspart 30（NovoRapid30） and pioglitazone.hydrochloride. Methods： A total of 60 cases of T2DM, whose blood glucose reached the control standard after two weeks＇NovoRapid30 intensive treatment, were allocated into the treatment group（29 cases） treated with NovoRapid30 and pioglitazone hydrochloride, and the control group （31 cases） treated with NovoRapid30 ; The blood glucose changes, HbAI C content, and insulin dose during different periods of the two groups were detected. Results： Compared with the control group, the blood glucose in the treatment group decreased significantly before breakfast and at 30 min, 60 min, and 120 min after 3 meals （P 〈 0.05 or 0.01 ）. The decrease of HbA1c was also obvious （P = 0. 042）. And the 24 h insulin consumption decreased （P 〈 0. 000 1 ）. Conclusion： The early combination of thiazolidinedione in the treatment of T2DM could decrease the insulin resistance and improve the blood glucose level.

关 键 词：2型糖尿病 胰岛素 盐酸吡格列酮 血糖 

分 类 号：R587.1[医药卫生—内分泌]