外遗调节与神经干细胞分化  

Epigenetic Regulation of Neural Stem Cell Fate

作　　者：赵明涛[1] 安志兴[1] 刘凤军[1] 张涌[1] 

机构地区：[1]西北农林科技大学动物科技学院,杨凌712100

出　　处：《细胞生物学杂志》2006年第4期523-526,共4页Chinese Journal of Cell Biology

摘　　要：神经发生与神经干细胞的分化调控机制是当今神经发育生物学的重要研究热点,在阐明干细胞的可塑性机制和临床治疗神经退行性疾病等方面具有广阔的应用前景。最近研究表明,外遗调节在神经干细胞的生长及分化方面表现出重要作用。这些外遗调节包括组蛋白的乙酰化/去乙酰化,DNA甲基化以及非编码RNAs对细胞命运决定的影响。Currently it is the focus of neural developmental biology to unravel the regulation of neurogenesis and differentiation mechanisms of neural stem cells, which have broad prospect in understanding the principle of the plasticity of stem cells and clinical therapy for neurodegenerative diseases. Recent studies have showed that epigenetic regulation plays an important role in the control of neural stem cell growth and differentiation. These epigenetic controls include the effects of histone acetylation/deacetylation, DNA methylation and noncoding RNAs on cell fate specification.

关 键 词：组蛋白乙酰化/去乙酰化 DNA甲基化 MIRNA 神经干细胞 

分 类 号：Q344[生物学—遗传学]