冷诱导细胞凋亡及其调控机制  

Cold-induced Apoptosis and Its Modulation Mechanism

作　　者：叶岚[1] 郑科[1] 傅宇[1] 万白羽[1] 童微星[2] 胡献明[3] 朱睦元[1] 

机构地区：[1]浙江大学生命科学学院,杭州310012 [2]浙江大学宁波理工学院,宁波315100 [3]衢州职业技术学院,衢州324000

出　　处：《细胞生物学杂志》2006年第4期551-555,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30370876)~~

摘　　要：冷和细胞凋亡有着密切的关系,冷诱导细胞凋亡的研究已经成为器官移植医学领域里的热点。冷诱导细胞凋亡的信号转导过程错综复杂,细胞内活性氧自由基、Ca2+、Fe2+以及冷相关基因都介导或调控冷引起的细胞凋亡。结合有关冷和细胞凋亡方面的研究进展,综述了与冷引起的细胞凋亡相关的信号转导过程和相关基因的调控机制。Cold and apoptosis are tightly correlated and the research on cold-induced apoptosis has become a hotspot within the transplantation medicine area. The signal transduction involved in the cold-induced apoptosis is anfractuous, either mediated or modulated by reactive oxygen species （ROS）, Ca^2＋, Fe^2＋ and cold-relevant genes in vivo. Based on the worldwide research progress, we try to generally summarize the signal transduction and modulation mechanism involved in the course of cold-induced apoptosis.

关 键 词：冷 细胞凋亡 活性氧 调控 信号转导 

分 类 号：R318.52[医药卫生—生物医学工程]