首乌降压胶囊对高血压病病人血压及RAAS的影响  

The Effect of Shouwujiangya Capsule on Hypertension and the Levels of Rennin,AngiotensinⅡ and Aldosterone in Plasma

作　　者：陈利昌[1] 易红[1] 

机构地区：[1]河南省三门峡市黄河医院

出　　处：《中西医结合心脑血管病杂志》2006年第9期754-755,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：河南省自然科学基金项目(No.0311043500)

摘　　要：目的观察首乌降压胶囊对高血压病病人血压、血浆肾素-血管紧张素-醛固酮系统(RAAS)的影响,探讨其临床疗效及作用机制。方法选取符合入选标准的病例68例,随机分为对照组34例与治疗组34例。对照组采用卡托普利片,每片25mg,每日3次,每次1片;治疗组服用首乌降压胶囊,每日3次,每次4粒。均以1个月为1个疗程。观察两组病人的血压、血浆RAAS指标的变化。结果两组治疗后血压较治疗前均明显下降(P<0.05),治疗组总有效率(94.1%)与对照组总有效率无差异(85.3%,P>0.05)。两组治疗后血浆肾素(PRA)、血管紧张素(AngⅡ)、醛固酮(ALD)水平较治疗前均下降(P<0.05)。结论首乌降压胶囊能降低和控制高血压病病人的血压。其降压机制可能与其降低血浆及肾脏组织PRA、AngⅡ、ALD水平有关。Objective To observe the effect of Shouwujiangya capsule on blood pressure, plasma rennin and angiotensin and aldosterone in patients （pts） with hypertension. Methods Sixty- eight pts with hypertension were divided into control group （n = 34 ） treated with captopril and treatment group （n = 34） treated with Shouwujiangya capsule. The blood pressure, plasma rennin and angiotensin and aldosterone were tested. Results In trial group, total effective rate was 94.1% （significantly effective was in 26 pts, effective in 6 pts, ineffective in 2 pts）. In control group, total effective rate was 85.3%. Blood pressure was significantly decreased （P 〈 0.05） in two groups and it was not obviously different between two groups（P 〉0.05）. Renin, angiotensin Ⅱ and aldosterone in plasma in two groups were significantly decreased （ P 〈 0.05 ）. Conclusion The findings suggested that Shouwujiangya capsule could decreased blood pressure, plasma renin, angiotensin Ⅱ and aldosterone. It＇s mechanism might be related to decrease of the levels of renin, angiotensin Ⅱ and aldosterone in plasma and kidney tissue.

关 键 词：首乌降压胶囊 高血压 肾 素 血管紧张素Ⅱ 醛固酮 

分 类 号：R259[医药卫生—中西医结合]