降压治疗对老老年高血压患者靶器官损害的影响  

The Effect of Antihypertensive Treatment on Target-Organ Damage in Very Elderly Patients

作　　者：刘振东[1] 路方红[1] 赵颖馨[1] 金世宽[1] 吴凡[1] 周晓红[1] 杨健民[1] 

机构地区：[1]山东省医学科学院基础医学研究所心脑血管疾病研究中心,济南250062

出　　处：《中国循证医学杂志》2006年第7期479-483,共5页Chinese Journal of Evidence-based Medicine

摘　　要：目的观察研究降压治疗对老老年高血压患者靶器官损害的影响。方法将167例老老年高血压患者随机分为降压治疗组和安慰剂对照组,对比治疗1年。对两组病例分别在治疗开始及治疗1年结束时各进行一次24 h动态血压监测、超声心动图检查和尿微量白蛋白、尿肌酐监测,并使用SPSS10．0软件包对所测的数据进行分析。结果治疗组治疗后动态血压指标中除日间舒张压、心率(24h、日间和夜间)外,其他指标改善均优于对照组(P<0．05);左心室各参数与肾功能指标的改善也优于对照组(P<0．05)。结论老老年高血压患者降压治疗后,左心室肥厚和肾功能损害明显改善。Objective To explore the effect of antihypertensive treatment on target-organ damage in very elderly patients （〉80 years）. Methods One hundred and sixty-seven very elderly hypertensive patients were randomized into two groups, i.e. anti-hypertension treatment group and placebo-control group. All the patients received echocardiographic examination of left ventricular mass index, laboratory tests of urinary creatinine and urinary albumin and 24-hour ambulatory blood pressure monitoring 2 months after placebo washout period and at the end of the one year treatment, respectively. Results After treatment, the improvement in all the dynamic blood pressure parameters except daytime diastolic blood pressure and heart rate（24 h, daytime and night time）, were significantly better than that of placebo-control group（P〈0.05）.The improvement in left ventricular and renal functional parameters were significantly better than that of placebo-control group（P〈0.05）. Conclusion Anti-hypertension treatment may significantly improve left ventricular pachynsis and renal function damage in very elderly hypertensive patients.

关 键 词：高血压 老年 老 靶器官损害 降压治疗 

分 类 号：R544.1[医药卫生—心血管疾病]