妇女骨质疏松过程的数值模拟  

Numerical simulation of process of osteoporosis in women

作　　者：马宗民[1] 李淑娴[2] 朱兴华[3] 

机构地区：[1]大连大学生物医学工程研究所,辽宁大连116021 [2]大连大学院士创业园,辽宁大连116622 [3]吉林大学工程力学系,吉林长春130025

出　　处：《大连大学学报》2006年第4期61-66,共6页Journal of Dalian University

基　　金：大连大学科技发展基金项目

摘　　要：[目的]进行妇女骨质疏松过程的数值模拟．[方法]应用带有力学调控系统的各向异性骨再造模型结合有限元法进行研究．[结果]在骨量下降初始阶段，下降平缓，绝经后骨量丢失加速，60岁时，骨量下降25．84％～28．63％，80岁时，骨量下降38．50％～40．44％，上述结果与临床观察结果基本一致．[结论]肌力下降是妇女骨质疏松的主要因素，绝经则加快了妇女骨质疏松的过程．本研究可用于指导临床妇女骨质疏松的防治．[ Objective] The process of osteoporosis in women is studied. [ Methods ] Anisotropic bone modeling model with mechanostat combining with finite element method are applied. [ Results] The results show that bone mass declines slowly at the beginning, loss of bone mass accelerates in postmenopause and bone mass declines 25.84% -28. 63% at the age of 60 and 38.50% -40. 44% at the age of 80. The result above is basically consistent with clinic result. [ Conclusions ] The decline of mechanical usage is primary factor leading to osteoporosis, and the menopause quickens the process of osteoporosis in women. The paper instructs the prevention and cure of osteoporosis in women clinically.

关 键 词：生物力学 骨质疏松 绝经 骨再造 模拟 

分 类 号：Q66[生物学—生物物理学]