吸入支气管舒张剂对COPD肺通气功能的影响  

Effect of inhaled bronchodilators on patients with COPD

作　　者：高新怀[1] 王立新[1] 吴秋云[1] 

机构地区：[1]江苏淮安市第一人民医院呼吸科,223300

出　　处：《临床肺科杂志》2006年第2期142-143,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨单药与联合吸入支气管舒张剂对COPD的疗效。方法50例患者随机分成A组(16例),B组(17例),C组(17例),分别测定基础肺功能。A组吸入溴化异丙托品,B组吸入沙美特罗/氟替卡松(舒利迭),C组吸入溴化异丙托品加舒利迭。于第1,8,15天测吸药后1h的功能参数FEV1、FVC。结果用药后各组FEV1、FVC较基础值有明显差异(P<0.01),C组△FEV1,△FVC明显高于A、B组,(P<0.01)。结论联合应用吸入支气管舒张剂对COPD患者有明显的气道扩张作用。Objective To evaluate the effects of inhaled bronchodilators on pulmonary function of COPD patients. Methods Fifty patients with COPD were divided into three groups at random： A, B and C. The baseline pulmonary function was measured separately. Group A inhaled ipratropium. Group B inhaled salmeterol xinatfoato and fluticasone propionate, Group C inhaled ipratropium salmeterol xinatfoato and fluticasone propionate. The subjects were tested on FEV1 and FVC on 1st. 8th and 15th days of the treatment. Results FEV1 and FVCincreased significantly in the three groups after inhalation （p〈0.01）. There was significant improvement of the mean peak percent increase in FEV1 and FVC over baseline in group C as compared with group A and group C （p〈0. 01 ）. Conclusion The inhalation of compound preparation has rapid and long bronchodilation on COPD patients.

关 键 词：慢性阻塞性肺病 支气管扩张剂 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]