GABA_B受体拮抗剂对小鼠学习记忆的促进作用  

IMPROVEMENT OF LEARNING AND MEMORY FUNCTIONS BY GABAB RECEPTOR ANTAGONISTS IN MICE

作　　者：俞在芳[1] 胡本荣[1] 程冠军[1] 

机构地区：[1]中山医科大学药理教研室,广州肿瘤研究所,上海医科大学神经生物学国家重点实验室

出　　处：《药学学报》1996年第11期801-805,共5页Acta Pharmaceutica Sinica

摘　　要：用一次性被动回避性条件反射方法，观察了ｒ－氨基丁酸（ＧＡＢＡ＿Ｂ）受体（ＧＢ－Ｒ）激动剂巴氯芬（ｂａｃｌｏｆｅｎ）及ＧＫ－Ｒ受体拮抗剂ＣＧＰ＿（３５３４８）和ＣＧＰ＿（３６７４２）对小鼠学习和记忆获得、巩固及再现的影响；结果表明，ＧＲ－Ｒ拮抗剂可显著改善巴氯芬所致的学习和记忆获得障碍，并能显著改善巴氯芬、亚硝酸钠所致的记忆巩固障碍及巴氯芬、乙醇所致的记忆再现障碍，提示ＧＢ－Ｒ拮抗剂有望成为新型治疗老年性痴呆的药物。In one trial passive avoidance response in mice,the effects of γ-aminobutyric acid(GABA)B receptor agonist baclofen and antagonist CGP35348 and CGP36742 on acquisition,consolidation and retrieval of memory were observed.The tesults showed that the antagonists couldsignificantly promote the acquisition impairment induced by baclofen, the consolidation impainnentinduced by baclofen and NaNO2,and the retrieval impairment induced by baclofen and 30 % alcohol.These results suggest that the GABA Breceptor antagonists may become a novel type of drug for thetreatment of Alzheimer'sdisease.

关 键 词：GABAB 受体拮抗剂 学习 记忆 氨基丁酸 

分 类 号：R971[医药卫生—药品]