蛋白激酶C抑制剂对沙土鼠和大鼠实验性脑缺血所致脑水肿的影响  

EFFECTS OF INHIBITOR OF PROTEIN KINASECON BRAIN EDEMA FORMATION EVOKED BY EXPERIMENTAL CEREBKAL ISCHEMIA IN GERBILS AND RATS

作　　者：胡振林[1] 谈冶雄[1] 张俊平[1] 钱定华[1] 

机构地区：[1]第二军医大学药学院中西药研究室

出　　处：《药学学报》1996年第12期886-890,共5页Acta Pharmaceutica Sinica

摘　　要：以沙土鼠单侧结扎颈总动脉造成单侧脑水肿病理模型，观察了两种蛋白激酶Ｃ（ＰＬＣ）抑制剂１－（５－异哆琳磺酞基）－２－甲基哌嗪（Ｈ－７）及苦参碱（Ｍａｔ）对实验性脑缺血所致的脑水肿的影响，结果表明：缺血前３０ｎｉｉｎｌｐＨ－７（６．２５和１２．５ｒｎｇ·ｋｇ－１）可有效减轻沙土鼠单侧结扎颈总动脉７ｈ所致的结扎侧脑半球的水肿程度，同时减少该侧脑半球电解质的蓄积；Ｍａｔ（２５和５０ｍｇ·ｋｇ－１）对沙上鼠单侧结扎颈总动脉７６以及ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠中动脉阻塞ｌｈ后再灌流２４ｈ所致的脑水４中均有防治作用。Recent studies have suggested that protein kinase C(PKC)may be involved in thefoimation of brain edema.In this paper,the effects of two kinds of PKC inhibitors,H-7 and matrine,were examined on the brain edema formation in experimental models.The resuIts showed thatpretreatment with H-7 6.25 and l2.5mg·kg-1 prevented the accumulation of water and certainelectrolytes in the unilateral hemisphere of the brain evoked.by ligation of a single common carotidartery in Mongolian gerbil; pretreatment with matrine 25 and 50 mg·k-1 reduced the extent ofcerebral edema foimation evoked by ligation of a single common carotid artery in gerbil and by middlecerebral artery occlusion in Sprague-Dawley rats.These resuIts present new evidence for theinvolvement of PKC in the formation of brain edema.

关 键 词：蛋白激酶 脑缺血 脑水肿 

分 类 号：R977.3[医药卫生—药品] R742.705[医药卫生—药学]