依那普利和牛磺酸逆转肾性高血压大鼠左心室肥厚及抗心律失常的作用  

EFFECTS OF ENALAPRIL AND TAURINE ON LEFT LENT VENTRICULAR HYPERTROPHY AND ARRHYTHMIA IN RENOVA8CULAR HYPERTENsIVE RAT

作　　者：陶亮[1] 饶曼人[1] 

机构地区：[1]南京医科大学心血管药理研究室,中山医科大学药理教研室

出　　处：《药学学报》1996年第12期891-896,共6页Acta Pharmaceutica Sinica

摘　　要：肾性高血压大鼠形成左心室肥厚后，心肌线粒体Ｃａ２＋含量和用成串电脉冲刺激离体心脏引起的心律失常发生率显著增高。依那普刊（６ｍｇ·ｋｇ－１），牛磺酸（３０ｍｇ·ｋｇ－１）在左心室肥厚形成后（术后第９周）开始连续ｐｏ给药９周，均能显著降低血压、左心室重与体重的比值、电刺激引起的心律失常发生率和心肌线粒体Ｃａ２＋含量，且两药合用后，降压作用增强，本实验表明，肾性高血压左心室肥厚大鼠的心脏对电刺激的敏感性增加．更容易产生心律失常；依那普利和牛磺酸对肾性高血压大鼠有降压、逆转左心室肥厚的作用，并能降低左心室肥厚大鼠的心脏对电刺激的敏感性。The effects of enalapril(Ena,6mg· kg-1)and taurine(Tau,30 mg· kg-1)onkRventricular hypertrophy(LVH ) and ventricular arrhythmia were studied in two-Kidney,one cliprenovascular hypertensive rats(RHR).From the 9th week after OPeration,Ena and Tau were givenper oral daily for 9 weeks.These drugs significantly decreased the systolic arterial pressure and theweight of the left ventricle. Combination of bOth drugs was found to reduce the blcod pressure furtherthan either dr7ug used alone, Arrhythmias induced by trains of electrical stimuli were more frequent inworking hearts isolated from RHR than that from norn1otensive rats.Ena and Tau could decrease theincidence of this arrhvthmias in RHR. The calcium content in the mvocardial mitochondria in RHRwas increased compared with that in norn1otensive rats.Treatment with Ena and Tau reduced thisincrease significantly.These resuIts suggest that chronic therapy with Ena and Tau can induce anattenuation of systemic arterial pressure and reduce the prOpensity of RHR heart to arrhythmOgenesisby limiting cardiac hypertrophy and calcium overload of the myocardium。

关 键 词：依那普利 牛磺酸 肾性高血压 心室肥厚 

分 类 号：R972[医药卫生—药品] R977.4[医药卫生—药学]