右旋酮洛芬的生产工艺进展  

Technology progress of the production of (S)-ketoprofen

作　　者：刘均洪[1] 曹雪莲[1] 

机构地区：[1]青岛科技大学化工学院药物工程实验室,山东青岛266042

出　　处：《化学工业与工程技术》2006年第4期22-25,共4页Journal of Chemical Industry & Engineering

基　　金：国家自然科学基金(20176019)

摘　　要：酮洛芬是一种非甾类抗炎药。介绍了生产酮洛芬单一对映体常用的动力学拆分法及该工艺过程存在的不足。指出了单一控制酶的细胞膜反应器的工艺技术更为经济,得到的对映异构体纯度高,产率大于50%。综述了当前右旋酮洛芬的不同生产工艺及存在的问题,并提出相应的整改措施。Ketoprofen is one of the nonstreroidal anti-inflamma- tory drugs.The production of single enantiomer of ketoprofen is ex- pected to grow due to its enantiomer displaying better pharmacologic activities.Kinetic resolution is the most widely used method in the production of enantiomer pure ketoprofen.However,the process has a number of limitations.The technology that operated under a single operating enzymatic membrane reactor system is more eco- nomical,more enantiomerically benign and has a maximum yield more than 50%.The current technology in the production of biologi- cally active(S)-ketoprofen,the limitations associated with the pro- duction and solutions to overcome these limitations are summard.

关 键 词：酮洛芬 对映体 动力学拆分 酶细胞膜反应器 

分 类 号：TQ463.2[化学工程—制药化工]