喜酞普兰与阿普唑仑治疗广泛性焦虑症对照研究  

A comparison study of citalopram versus alprazolam in the treatment of generalized anxiety disorder

作　　者：程勇[1] 李志刚[1] 王贤庆 

机构地区：[1]泰安市复员退伍军人精神病院,山东泰安271000 [2]湖北省天门市精神病院

出　　处：《中国民康医学》2006年第17期735-736,共2页Medical Journal of Chinese People’s Health

摘　　要：目的：探讨喜酞普兰治疗广泛性焦虑症的临床疗效和安全性。方法：将73例广泛性焦虑症患者随机分为喜酞普兰组36例和阿普唑仑组37例，喜酞普兰组治疗剂量在10～50mg／d，阿普唑仑组为1．2～3．6mg／d，观察时间为6周。疗效评定采用汉密尔顿焦虑量表（HAMA）和焦虑自评量表（SAS），安全性评价用不良反应症状量表（TESS）、实验室检查及查体。结果：喜酞普兰组显效率为69．4％，有效率为91．7％；阿普唑仑组显效率和有效率分别为67．6％和89．2％，两者疗效相当，但中长期疗效喜酞普兰则占优；喜酞普兰组不良反应发生例次明显少于阿普唑仑组（P〈0．01），程度均较轻微。结论：喜酞普兰治疗广泛性焦虑症疗效肯定，安全性高，依从性好。Objective：To explore the efficacy and safety of citalopram in the treatment of generalized anxietv disorder. Methods：A total of 73 patients with generalized anxiety disorder were randomly divided into citalopram group and alprazolam group, and both groups were followed up for 6 weeks. The efficacy and Safety were evaluated with HAMA,SAS and TESS. Results： The significant improvement rate and the responsive rate of citalopram group and alprazolam group were 69.4% and 91.7% ,67.6% and 89.2% respectively, and there were no significant differences between the two groups. But citalopram was better in the metaphase and later,The occurrence of side effects was much less for citalopram in comparison with alprazolam （ P 〈 0.01 ） , and the side effects were mild. Conclusions： Citalopram is effective in the treatment of geheralized anxiety disorder with mild side effects and good compliance.

关 键 词：喜酞普兰 阿普唑仑 广泛性焦虑症 

分 类 号：R971.43[医药卫生—药品] R749.72[医药卫生—药学]