麦普替林联合氟西汀治疗抑郁症的疗效对比分析  

A comparative study of maprotiline plus fiuoxetine in treatment of depression.

作　　者：杨忠[1] 尹建兵[1] 邓丽红[1] 宋静波[1] 马友根 

机构地区：[1]江苏省常熟市第三人民医院心身科,江苏常熟215558

出　　处：《中国民康医学》2006年第17期757-758,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:评价麦普替林联合氟西汀治疗抑郁症的临床疗效和安全性。方法:将符合CCMD-3抑郁症诊断标准的61例抑郁症患者随机分为治疗组(麦普替林联合氟西汀组)(31例)和对照组(氟西汀组)(30例),治疗6周。用汉密顿抑郁量表(HAMD)评定疗效,用抗抑郁药副反应量表(SERS)评定不良反应。结果:治疗组和对照组的有效率分别为84%和77%,两者比较差异无显著性,但治疗组的痊愈率达到65%和对照组37%相比差异有显著性,同时治疗组的起效比对照组快。结论:麦普替林联合氟西汀治疗抑郁症是一种恰当的联合治疗方法。Objective：The aim of this study was to determine the efficacy and safety of maprotiline plus fluoxetine for the depressive patients. Methods：A controlled study was carried out between 61 patients who met the CCMD -3 criteriaon of major depression. The 31 of total patients were treated with maprotiline plus fluoxetine（ therapeutic group ） and the others were treated with fluoxetine （control group） for 6 weeks. The efficacy was assessed by Hamilton depression rating scale（HAMD） and the safety was assessed by Rating Scale for Side Effects（SERS）. Results： After 6 weeks treatment, the efficacy rate of the therapeutic group and control group were 84% and 77% , respectively. The results have no remarkable differences in two groups（ P 〉 0.05 ）, but therapeutic groupg conva- lescing rate achieved 65% and the control group 37% , The results have remarkable differences in two groups （ P 〈 0.05 ） . and the therapeutic group took effect more quickly. Conclusions： maprotiline plus fluoxetine is an appropriate method in treatment of depression.

关 键 词：麦普替林 氟西汀 抑郁症 

分 类 号：R971.43[医药卫生—药品] R749.41[医药卫生—药学]