HPMC配制萘普生骨架型缓释颗粒胶囊的试验  

The Matrix Sustained-release Granular Capsule of Naproxen Prepared with HPMC

作　　者：陈远航[1] 黄东亮 钟柳芳 

机构地区：[1]广州市番禺区中医院,311400 [2]深圳一致药业股份有限公司,518029 [3]广州市药检所第五分所,311400

出　　处：《医药世界》2006年第8期51-53,共3页Medicine World

摘　　要：目的:研究萘普生骨架型缓释颗粒胶囊的制备,减少给药次数,降低不良反应。方法采用硬脂酸包裹和羟丙甲基纤维素(HPMC)水凝胶缓释技术及UV测定法,研究了萘普生骨架型缓释颗粒胶囊并进行初步稳定性试验。结果萘普生检测浓度在10．0-50．0μg?ml-1范围内,紫外吸收值(A)与浓度(C)有良好线性关系,r=0．9987;本品缓释效果明显,12h内药物释放曲线符合Higuchi方程,属于扩散释药机制。结论本缓释胶囊处方合理工艺简单,有理想的缓释效果。OBJECTIVE： To study the preparation of matrix sustained release granular capsule of naproxen so as to reduce the administration times and adverse effects of the drug. METHODS： The stearic acid coating, hydroxypropyl methylcellulose（HPMC） hydrogel sustained-release and ultraviolet measurement technology were undertaken to study the naproxen matrix sustained-release granular capsule and an initial stability test was also done. RESULTS： The detected range of naproxen concentration lay between 10.0 to 50.0 μ g, while the absorption value and concentration had a good linear relationship, r=0.9987（the regression coefficient）. The product had obvious sustained-release effect, while its release curve within 12 hours complied with the Higuchi equation, which coincided with the diffuse release mechanism. CONCLUSIONS： The sustained release capsule had a reasonable prescription and simple craft. It has ideal sustained release effects.

关 键 词：萘普生 骨架型缓释胶囊 水凝胶缓释技术 释放度 

分 类 号：R965.3[医药卫生—药理学]