四带曲霉引起肺曲霉病国内首例报告  

A Case of Pulmonary Aspergillosis Caused by Aspergillus Tetrazonus

作　　者：王家俊[1] 章强强[1] 李莉[1] 

机构地区：[1]上海医科大学华山医院皮肤科真菌室,200040

出　　处：《中华皮肤科杂志》1996年第5期311-312,共2页Chinese Journal of Dermatology

摘　　要：1例白血病患者化疗期间因反复出现高热、咳嗽和持续的肺部阴影而作真菌学检查。痰直接涂片有分枝分隔粗的菌丝。病变部位组织病理见扭曲短粗极少分枝的菌丝,部分呈"孢子状"。痰多次培养均为同一菌种。该菌种在蔡氏培养基上生长快,37℃时生长良好。菌落表面粉状或颗粒状,紫色。分生孢子头短柱状,淡绿色,60～70μm×30～40μm。分生孢子梗棕色,壁光滑。顶囊半球形,其上产孢结构2列,长度接近。分生孢子球形,表面粗糙有小棘。闭囊壳球形,壁单层,黄色。外围有大量球形厚壁,直径约25μm的壳细胞。闭囊壳内含大量子囊,紫红色;子囊内含8个子囊孢子,子囊孢子紫蓝到紫红色,双凸镜状,表面光滑;约5μm×4μm直径。其上有两对脊,一对较大,一对较小,较小的一对有时不清楚。菌种鉴定为四带曲霉,这是四带曲霉引起人肺曲霉病的首次报告。A strain of Aspergillus isolated from a patient with leukemia was confirmed as As- pergillus Tetrazonus histopathologically and mycologically.Biopsy showed thick,short,globose and distorted hyphae in pulmonary tissue.Colonies on Czapek's agar grew well at 37℃.The surface was purplish with floccosity in some area.Conidial heads were short,columnar,light green,60～70×30～ 40μm in size.Stipes were smooth-walled,dull brownish in color.Vesicles were hemispherical 7～9μm in diameter.Conidia were globose,pale yellowish green and rugose.Cleistothecia enveloped by thick walled hull ceils were spherical,and 120～150μm in diameter.Ascospores were purplish red,smooth- walled with two pleated equatorial crests paralleled by a secondary narrower pair of crests which were sometimes indistinct.As a pathogenic species,this is a first report in China.

关 键 词：四带曲霉 肺曲霉病 曲霉病 诊断 病例报告 

分 类 号：R519.804[医药卫生—内科学]