蛙粪霉病一例报告(附超微结构观察)  

Basidiobolomycosis:A Case Report and Its Ultrastructural Changes

作　　者：薛筑云[1] 程宝庚[2] 郁辉[1] 余美玲[1] 梅亚灵[3] 

机构地区：[1]南京医科大学第一附属医院皮肤科,210029 [2]南京医科大学电镜室 [3]南京医科大学第一附属医院细菌室,210029

出　　处：《中华皮肤科杂志》1996年第5期316-318,共3页Chinese Journal of Dermatology

摘　　要：对1例蛙粪霉病的临床经过作了报道,并作了组织病理、超微结构和真菌学检查。结果表明:①使用皮质类固醇期间,由于炎症反应被部分抑制,临床表现相对静止,机体虽有防御反应,病灶内致病菌仍然生长良好,繁殖旺盛,一定条件下发生了病灶播散。②使用伊曲康唑期间,药物通过破坏真菌细胞膜,导致抑菌和杀菌;发挥与机体防御系统的协同性而增强疗效。在药物作用下,大量真菌崩解,促发较强烈的急性炎症反应,继之,真菌被清除,病灶吸收和修复,在其演变过程中形成脓肿和纤维化结节,辅以相应的手术治疗,缩短了疗程。A patient with basidiobolomycosis is reported,the clinical course described,the ultra- structural and histologic changes observed,and mycologic examination was made.The results indicated that:(1)In the course of using corticosteroids,because the inflammatory reaction was suppressed par- tially,the clinical manifestation was relatively relieved.In the loci the pathogenic fungi still grew well, and focal dissemination was observed;(2) In the course of using itraconazole,the drug exerted fungistatic and fungicidal action through the destruction of cell membranes of fungi.Meanwhile,itra- conazole also exerted a synergistic action with the defense function of the human body,resulting in an enhanced therapeutic effects.The strong acute inflammatory reaction was triggered by the destroyed fungi caused by itraconazole.Then the fungi were cleared,the lesions were absorbed and repaired.Sur- gical intervention may be helpful to remove abscesses and fibrous nodules formed in the clinical course, so as to shorten the course of treatment.

关 键 词：蛙粪霉病 伊曲康唑 药物疗法 超微结构 

分 类 号：R519.05[医药卫生—内科学]