水溶性梳状聚乙二醇构建的血液相容性涂层  

CONSTRUCTION OF A BLOOD COMPATIBLE COATING VIA AMPHIPHILIC COMB-LIKE POLY(ETHYLENE GLYCOL)

作　　者：浦鸣[1] 计剑[1] 李晓林[1] 沈家骢[1] 

机构地区：[1]浙江大学高分子科学与工程系高分子合成与功能构造教育部重点实验室,杭州310027

出　　处：《高分子学报》2006年第5期703-706,共4页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号50373036);国家重点基础研究规划项目(973)(项目号2005CB623902);教育部霍英东基金优选(项目号J20040212)资助项目

摘　　要：A water soluble hydroxy-capped comb-like poly(ethylene glycol)(CPEG) was prepared via atom transfer radical polymerization(ATRP).A stable CPEG coating was obtained via dip-coating followed by curing at 70℃ for 48 h.The CPEG-modified surface was proved to be stable in both aqueous environment and ambient according to contact angle behavior and weight decrement testing.The coating forming mechanism was investigated through FTIR,the spectra data demonstrated the stability of CPEG coating derived from its hydrogen bond of inter-molecules and intra-molecules.Platelet experiment showed CPEG modified surface reacted extremely weakly with platelet and showed excellent thrombus resistance than that of both on the pure PET surface and PET surface modified with linear PEG.The model drug RD6G was applied to fabricate a drug-buried CPEG coating surface.The drug-releasing curve demonstrated the stability of the CPEG coating and the controlled-release behavior of RD6G.The unique property of CPEG coating surface provided the potential application in the immobilization and release of aqueous drug,including protein and peptide.A water soluble hydroxy-capped comb-like poly （ethylene glycol ） （CPEG） was prepared via atom transfer radical polymerization （ATRP） . A stable CPEG coating was obtained via dip-coating followed by curing at 70℃ for 48 h. The CPEG-modified surface was proved to be stable in both aqueous environment and ambient according to contact angle behavior and weight decrement testing. The coating forming mechanism was investigated through FTIR, the spectra data demonstrated the stability of CPEG coating derived from its hydrogen bond of intermolecules and intra-molecules. Platelet experiment showed CPEG modified surface reacted extremely weakly with platelet and showed excellent thrombus resistance than that of both on the pure PET surface and PET surface modified with linear PEG. The model drug RD6G was applied to fabricate a drug-buried CPEG coating surface. The drug-releasing curve demonstrated the stability of the CPEG coating and the controlled-release behavior of RD6G. The unique property of CPEG coating surface provided the potential application in the immobilization and release of aqueous drug, including protein and peptide.

关 键 词：血液相容性 梳状聚乙二醇 涂层 药物释放 

分 类 号：R318.08[医药卫生—生物医学工程]