以甘-谷二肽为构筑单元的扇形树状分子的合成与表征  

SYNTHESIS AND CHARACTERIZATION OF PEPTIDE DENDRONS WITH GLY-GLU AS BUILDING BLOCKS

作　　者：李武松[1] 吉岩[1] 贾欣茹[1] 王冰冰[1] 危岩 

机构地区：[1]北京大学化学与分子工程学院,北京100871 [2]Department of Chemistry Drexel University

出　　处：《高分子学报》2006年第5期712-716,共5页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号2037400220574001)资助项目

摘　　要：The synthesis and characterization of a series of peptide dendronswith glycin（Gly） and glutamate（Glu） as building blocks were described.The dendrons were prepared with convergent method by protection,deprotection and DCC coupling reactions.With the characterization of elemental analysis,（）1H-NMR,（）13C-NMR,FTIR,EI-MS and MAILD-TOF MS,the designed molecular structure was proved.It could be predicted that the obtained compounds will exhibit unique properties and potential applications in the fields of biology,medicine and so on.Further studies on the properties of these compounds are in progress.The synthesis and characterization of a series of peptide dendronswith glycin （Gly） and glutamate （Glu） as building blocks were described. The dendrons were prepared with convergent method by protection, deprotection and DCC coupling reactions. With the characterization of elemental analysis, ^1 H-NMR, ^13 C-NMR, FTIR, El-MS and MAILD-TOF MS,the designed molecular structure was proved. It could be predicted that the obtained compounds will exhibit unique properties and potential applications in the fields of biology, medicine and so on. Further studies on the properties of these compounds are in progress.

关 键 词：甘氨酸-谷氨酸 树枝状分子 多肽合成 MALDI—TOF 

分 类 号：O629.72[理学—有机化学]