聚肽嵌段共聚物中肽链构象对其自组装行为的影响  

THE EFFECT OF POLYPEPTIDE CHAIN CONFORMATION ON THE SELF-ASSEMBLY BEHAVIOR OF ITS BLOCK COPOLYMER

作　　者：朱国全[1] 陈涛[1] 林嘉平[1] 董秀斌[1] 

机构地区：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237

出　　处：《高分子学报》2006年第5期732-735,共4页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号50273011;20574018);上海市曙光计划(项目号02SG025);教育部博士点基金(基金号20050251008);上海市科学技术委员会纳米专项基金(基金号0352nm109)资助项目

摘　　要：Polymeric micelles were prepared by dropping ethanol into solutions containing（poly（γ-benzyl L-）glutamate）-poly（ethylene oxide） block copolymer （PBLG-b-PEO）,chloroform（CHCl3） and trifluoroacetic acid（TFA）.Viscometry,transmission electron microscopy（TEM）,nuclear magnetic resonance（（）1H-NMR） spectroscopy and infra-red difference spectroscopy（IR） were used to investigate the influence of PBLG chain conformation on the self-assembly behavior of PBLG-b-PEO.The experimental results revealed that PBLG-b-PEO could associate into polymeric micelles in ethanol solutions.The introduction of TFA not only changes the conformation of PBLG segments,but also increases the critical micelle concentration,and further affects the morphologies of the formed micelles.Polymeric micelles were prepared by dropping ethanol into solutions containing poly（ γ-benzyl L- glutamate）-poly （ ethylene oxide ） block copolymer （ PBLG- b-PEO ）, chloroform （ CHCl3 ） and trifluoroacetic acid （TFA）. Viscometry, transmission electron microscopy （TEM）, nuclear magnetic resonance （ ^1 H-NMR） spectroscopy and infra-red difference spectroscopy （IR） were used to investigate the influence of PBLG chain conformation on the self-assembly behavior of PBLG-b-PEO. The experimental results revealed that PBLG-b-PEO could associate into polymeric micelles in ethanol solutions. The introduction of TFA not only changes the conformation of PBLG segments,but also increases the critical micelle concentration, and further affects the morphologies of the formed micelles.

关 键 词：聚肽共聚物 自组装 临界胶束浓度 分子链构象 

分 类 号：O631.3[理学—高分子化学]