微管抑制剂那可丁及其衍生物的抗肿瘤作用研究进展  

Microtubule interfering agents: noscapine and its derivatives

作　　者：魏少荫[1] 李敏[1] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,北京100083

出　　处：《中国新药杂志》2006年第15期1238-1243,共6页Chinese Journal of New Drugs

摘　　要：过去几十年中,那可丁一直被用作镇咳药。近年来发现那可丁及其衍生物可作用于微管,抑制其动态不稳定性,从而干扰肿瘤细胞的有丝分裂,起到抗肿瘤作用。体内实验研究发现,那可丁及其衍生物抗肿瘤活性高、广谱、毒副作用不明显,有望被开发为抗肿瘤新药。Noscapine has been primarily used as antitussive agent for several decades. Recent researches found that noscapine and its derivatives cause growth arrest of tumor cells in mitosis and induce apoptosis of tumor cells in vitro by interfering tubulin conformation and microtubule dynamics. As a matter of facts that noscapine and its derivatives show effectiveness against the growth of several tumor cells and little or no toxicity to human body, they have the potential to be an effective chemotherapeutic agent for the treatment of human cancers.

关 键 词：那可丁 抗肿瘤 微管 微管蛋白 

分 类 号：R979.1[医药卫生—药品]