氯吡格雷治疗非ST段抬高ACS疗效观察  

Clinical Study of Clopidogrel in Non-ST-elemate ACS

作　　者：张琳[1] 孙慧灵[1] 吴琳[1] 

机构地区：[1]郑州市中心医院心内科,郑州市450007

出　　处：《医药论坛杂志》2006年第14期19-20,共2页Journal of Medical Forum

摘　　要：目的研究氯吡格雷和噻氯匹啶治疗不稳定性心绞痛(UA)和非ST段抬高心肌梗塞(NSTEM I)的临床疗效。方法非ST段抬高急性冠脉综合征患者共112例,随机分为两组。治疗组56例,氯吡格雷75mgqd;对照组56例,噻氯匹啶250mg B id,14天后改为250mg qd。两组患者均同时应用阿司匹林、低分子肝素等,基础治疗相同。随访3个月。统计两组治疗后心脏事件的发生率和不良反应。结果治疗3个月后,两组患者心脏事件发生率相似,但氯吡格雷组的粒细胞减少发生率低(0比5.4%),胃肠道反应少(7.1%比16.1%),皮疹发生少(3.6%比12.5%),停药发生少(1.8%比8.9%)。结论氯吡格雷治疗非ST段抬高急性冠脉综合征疗效与噻氯匹啶相当,不良反应发生率低,患者依从性好。Objective To study the effect of Clopidogrel and Ticlopidine on unstable angina （UA） and non -ST elemate myocardiol infarction （NSTEMI）. Methods 112 patients with UA/NSTEMI were divided into 2 groups randomly. The treatment group 56 cases was administrated Clopidogrel 75mg qd. The control group was treated by Ticlopidine 250mg bid for 14 days followed by 250mg qd. All patients were followed up for 3 months. The incidence of cardiac event and adverse effect of two groups were observed. Results After 3 months follow - up, the incidence of cardiac event of two groups had no significant difference. In Clopidogrel group, patients had less granulocytopenia （0 vs 5.4% ）, gastrointestinal tract response （7.1% vs 16.1% ）, exanthem（3.6% vs 12.5% ） and drug withdrawal （ 1.8% vs 8.9% ）. Conclusion Clopidogrel has the same effect on UA/NSTEMI with fewer sideeffect and drug withdrawal than Ticlopidine.

关 键 词：氯吡格雷 急性冠脉综合征 UA/NSTEMI 

分 类 号：R541[医药卫生—心血管疾病]