格列吡嗪控释片联用甘精胰岛素的疗效及β细胞功能变化  

Effect of combined treatment of glargine and gllpizide GITS on metabolic control and β-cell function

作　　者：黄云鸿[1] 蒋筠[1] 吴艺捷[1] 彭永德[1] 

机构地区：[1]上海交通大学附属第一人民医院内分泌科,200080

出　　处：《中华内分泌代谢杂志》2006年第4期321-322,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：为探讨磺脲类继发性失效者联合甘精胰岛素的疗效,改用格列吡嗪控释片联合睡前注射甘精胰岛素(20例)或中性鱼精蛋白锌胰岛素(32例)。16周后两组血糖和HbAIC均下降,但甘精胰岛素组低血糖较少,且治疗后C肽升高。故联合甘精胰岛素有较好疗效,并可能改善β细胞功能。Diabetic patients with secondary sulfonylureas failure were shifted to glipizide plus glargine （ n =20） or neutral protamine hagedorn （n=32）. Sixteen weeks later, blood glucose and HbA1c were decreased and serum C peptide level increased in both groups. Hypoglycemia occurred less frequently and β-cell function was improved in glargine group.

关 键 词：格列吡嗪 甘精胰岛素 胰岛Β细胞功能 

分 类 号：R587.1[医药卫生—内分泌] R512.91[医药卫生—内科学]