动态血糖监测探讨2型糖尿病患者睡前血糖和夜间低血糖的关系  

Relationship between bedtime blood glucose level and nocturnal hypoglycemia observed with continuous glucose monitoring system in type 2 diabetic patients

作　　者：吴国富 麦一峰 罗薇 于春艳 吴银环 焦江萍 

机构地区：[1]镇海龙赛医院内分泌科,宁波315200

出　　处：《中华内分泌代谢杂志》2006年第4期323-324,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：85例2型糖尿病患者使用动态血糖监测系统(CGMS)监测血糖,每例记录48-72 h,共计完整记录220 d。以睡前血糖≤4．4 mmol／L,≤5．0 mmoL／L,≤5．6 mmol／L,≤6．1 mmol／L,≤6．7 mmol／L,≤7．2 mmol／L,评估这些患者的夜间低血糖(《2．8 mmol／L)的发生情况。26例患者39夜发生夜间低血糖,他们的睡前血糖为(4．4±2．6)mmol／L(2．2-12．6 mmoL／L)。在睡前血糖≤6．7 mmol／L时ROC曲线下面积达最大值(0．359±0．046),其阳性预测值25．0％,阴性预测值91．7％。CGMS是诊断夜间无症状性低血糖的有效方法。Blood glucose levels of 220 days were recorded in 85 type 2 diabetic patients for monitoring glycemia for 48-72 h each one by the continuous glucose monitoring system（CGMS）. Frequencies of nocturnal hypoglycemia （blood glucose≤2, 8mmol/L） were estimated when bedtime blood glucose levels were ≤4.4mmol/ L, ≤5, 0mmol/L, ≤5, 6mmol/L, ≤ 6. lmmol/L, ≤ 6, 7mmol/L, or ≤7. 2mmol/L respectively. Nocturnal hypoglycemia occurred in 39 nights of 220 days （ 17.7% ） of 26 patients and their bedtime blood glucose level was （4.4 ±2.6）mmol./L with a range from 2.2 to 12.6 mmol./L, Using a cut-off of bedtime blood glucose at ≤6.7 mmol/L, area under the ROC curve was reached maximal value （0,359 ± 0. 046）. The positive predictive value was 25% and the negative predictive value was 91. 7%. CGMS is a useful tool to detect unaware nocturnal hypoglycemia.

关 键 词：糖尿病 2型 动态血糖监测系统 低血糖 夜间 

分 类 号：R587.1[医药卫生—内分泌] R473.5[医药卫生—内科学]