^(60)Co γ射线照射与去白细胞血血浆部分细胞因子含量变化的研究  

Study on changes of the plasma cytokines in ^(60)Co γ-ray irradiated blood and leukocyte reduction of whole blood

作　　者：李志强[1] 乐嘉宜 瞿益华[1] 徐文皓[1] 

机构地区：[1]上海交通大学附属第六人民医院,200233 [2]上海黄浦区中西医结合医院

出　　处：《中华放射医学与防护杂志》2006年第4期349-351,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：上海市卫生局科技发展基金资助项目(034054)

摘　　要：目的探讨60Co γ射线照射与去白细胞血血浆IL-2、IL-6、INF-γ与TNF-α含量的变化和患者输注后的发热情况。方法应用ELISA法检测经60Coγ射线照射与去白细胞过滤血血浆IL-2、IL-6、INF-γ和TNF-α的含量。结果随着保存期的延长,经60Coγ射线照射与去白细胞过滤血血浆IL-2、IL-6、INF-γ和TNF-α含量变化不很明显;并经60Coγ射线照射或去白细胞过滤血液给患者输注后的发热现象均明显减少。结论60Coγ射线照射血液制品输注在有效预防输血相关性移植物抗宿主病的同时也能有效减少非溶血性发热输血反应的发生。Objective To study the changes of IL-2, IL-6, IFN-y and TNF-a in ^6o Co γ-ray irradiated and leukocyte reduction of whole blood, and to understand the fever phenomenon in patients received blood transfusion. Methods ELISA method was used to measure changes of the eytokines. Results The plasma levels of IL-2, IL-6, IFN-y and TNF-a did not change significantly with extending the conservation period both in ^6o Co-irradiated and leukocyte reduction of whole blood. The frequency of fever deereaed obviously with transfusion of ^60Co-irradiated and leukocyte reduction of whole blood. Conclusion ^60Co-irradiated blood can not only prevent transfusion associated graft-versus-host disease （TA-GVHD）, but also decrease non-hemolytic febrile transfusion reactions （NHFTR） effectively.

关 键 词：^60CO Γ射线 照射 去白细胞过滤器 血液 细胞因子 

分 类 号：R457[医药卫生—治疗学]