呼吸道合胞病毒及其他病毒性肺炎患儿血淋巴细胞亚群的变化  

Changes of Lymphocyte Subsets in Children with Pneumonia Infected with Respiratory Syncytial Virus and Other Virus

作　　者：马兰[1] 侯安存[1] 杭敏[1] 卢炎[1] 刘霞[1] 

机构地区：[1]首都医科大学附属北京友谊医院儿科,北京100050

出　　处：《实用儿科临床杂志》2006年第16期1058-1059,共2页Journal of Applied Clinical Pediatrics

基　　金：北京市中医管理局重点扶植项目资助(210-4)

摘　　要：目的了解不同病原所致病毒性肺炎时血淋巴细胞亚群的改变。方法对2002～2004年确诊为病毒性肺炎的住院患儿，采用流式细胞仪对其急性期血淋巴细胞亚群进行检测。其中呼吸道合胞病毒（RSV）性肺炎组34例，非RSV肺炎组23例。同时与30例健康对照组比较。结果非RSV组Th1细胞百分率为[（15．89±7．88）％]，RSV肺炎组为[（11．76±7．31）％]，均较对照组显著增高（P=0．011，0）；两者亦有显著差异（P=0．026）；Th1／Th2在非RSV肺炎组较RSV肺炎组及对照组均明显增高，有非常显著差异（P=0．006，0）。结论病毒性肺炎时呈现Th1应答优势，并以非RSV感染最为明显。与非RSV肺炎相比，RSV威诳且右潜在的相对Th，后商俪向．Objective To study the changes of lymphocytes subsets including Thl and Th2 cells in pulmonary blood mixing volume of children with respiratory syncytial virus（RSV） and non - RSV viral pneumonia in acute period. Methods Fresh peripheral blood samples of patients in 34 RSV- group and 23 non - RSV- group were collected and run through the flow cytometry, while 30 healthy children as controls. The percentage of lymphocytes subsets were acquired using Simucset IMK - Lymphcyte software. Results The percentage of Thl cell was [（15.89±7.88）% ] and [（11.76±7.31）% ]in non- RSV and RSV group, respectively. Both of them were higher than there in control group（ P = 0.011,0）, and there was significant difference between two groups. The ratio of Th1/Th2 in non - RSV viral pneumonia group was also higher than that in RSV group （ P = 0. 006） and control group（ P = 0 ）. Conclusions There are Thl predominant response in viral pneumonia group, and it is more obviously in non- RSV group. Compared with non - RSV group, the potential and relative Th2 trend is noted in RSV pneumonia.

关 键 词：肺炎 病毒性 淋巴细胞亚群 流式细胞术 

分 类 号：R725.6[医药卫生—儿科]