十一酸睾酮对心力衰竭雄兔心功能的影响  

The Effect of Testosterone Undecanoic Acid Replacement Therapy on Heart Function in Male Rabbits with Congestive Heart Failure

作　　者：娄卫民[1] 李小鹰[1] 李金生[2] 樊瑾[1] 沈正[2] 

机构地区：[1]中国人民解放军总医院老年心内科,北京100853 [2]贵阳医学院附院心内科,贵州贵阳550004

出　　处：《贵阳医学院学报》2006年第4期310-312,316,共4页Journal of Guiyang Medical College

基　　金：总后卫生部临床高新技术重大项目建设基金([2002]卫医字18号)

摘　　要：目的:评价十一酸睾酮(TU)对心力衰竭雄兔心功能的影响。方法:将40只雄性新西兰大白兔随机分为假手术组(n=8)和模型组(n=32)。3周后将模型组中20只经心脏超声检查证实心力衰竭的雄兔随机分为对照组和TU组,每组10只,其中对照组和假手术组予生理盐水1 m l肌肉注射,1次/2周;TU组予TU 3mg/kg肌肉注射,1次/2周。治疗3个月后复查心脏超声,处死后称体重并取心脏标本称重。结果:(1)治疗前对照组和模型组的左心室射血分数(LVEF)、左室短轴缩短率(FS)、左室收缩内径(LVSD)、左室舒张内径(LVDD)均显著低于假手术组;对照组以上参数治疗前、后无变化,但FS、LVEF低于假手术组(P<0.05),LVDD、LVSD则明显高于假手术组(P<0.05);治疗3个月后TU组FS、LVEF较治疗前增加(P<0.05),与假手术组比较无显著差异。(2)治疗3个月后假手术组心脏重量与体重比值(2.2±0.3)‰,对照组显著高于假手术组为(2.7±0.3)‰,而TU组与假手术组无显著差异为(2.4±0.4)‰,(P>0.05)。结论:TU替代治疗可改善心力衰竭雄兔的心功能。Objective： To study the effect of testosterone undecanoic acid replacement therapy （TU） on heart function in male rabbits with congestive heart failure （CHF）. Methods： Forty male New Zealand rabbits aged 16 -20 weeks were randomly divided into sham operation group （SOG, n = 8 ） and myocardial infarction group （ MIG, n = 32）. Twenty male rabbits with myocardial infarction had CHF were confirmed by ultracardiography （UCG）. Twenty survived CHF model rabbits were randomly divided into control group （CG, n = 10） and testosterone undecanoic acid group （TUG, n = 10）. Rabbits in group TUG received testosterone undecanoic acid intramuscular injection at a dose of 3mg/kg/ 2weeks for 3 months, while those in group CG received normal saline instead. Heart function was evaluated by UCG and heart/body weight rate （HBW） measured at the end of the investigation. Results： （ 1 ） Before the treatment, the left ventricular ejection fraction （ LVEF）, left ventricular fraction shortening （FS）, left ventricular end-systolic dimension （LVSD）, and left ventricular end-diastolic dimension （LVDD） in groups CG and MIG were lower than those in group SOG significantly. All the parameters in group CG did not change after the treatment, but FS, LVEF were still lower and LVDD, LVSD higher than those in group SOG （P 〈0.05）. In group TUG, FS, LVEF increased（P 〈0.05） after 3 months of treatment, and reach the levels of those in group SOG. （2） After 3 months of treatment, the HBW was 2.2±0.3‰ in group SOG, 2.7±0.3‰ in group CG （higher than that of group SOG, P 〈 0. 05 ）, and 2.4±0.4‰ in group TUG （ no difference from that of group SOG, P 〉 0.05 ）. Conclusion： TU replacement therapy with physical dosage can improve heart function in male CHF rabbits.

关 键 词：心力衰竭 充血性 心室功能 左 睾酮 兔 

分 类 号：R541.61[医药卫生—心血管疾病]