急性心肌梗死与TH1/TH2应答的关系  

A Study on the Relationship of Acute Myocardial Infarction and TH1/TH2 Response

作　　者：申延伟 姜吉熙 任玮[2] 邱红梅[3] 左丽[2] 

机构地区：[1]贵州省电力职工医院内科,贵州贵阳550002 [2]贵阳医学院免疫学教研室,贵州贵阳550004 [3]贵州省人民医院心内科,贵州贵阳550002

出　　处：《贵阳医学院学报》2006年第4期330-332,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨TH1/TH2应答与急性心肌梗死发作的关系。方法:采用双抗体夹心酶联吸附法(ELISA),测定27例急性心肌梗死及29例健康者血清IFN-r、TNF-а及IL4、IL-6、IL-10、TGF-β1水平。结果:(1)急性心肌梗死患者血浆中IFN-r水平低于正常人,且治疗前低于治疗后(P<0.01);治疗前病人血清中TNF-а水平与正常人比较无明显统计学意义,但治疗后高于治疗前,且有统计学意义(P<0.001)。(2)心肌梗死患者在治疗前后血浆IL-6水平均明显高于正常人(P<0.05),且治疗后明显低于治疗前(P<0.01);正常人血清中TGF-β1水平明显高于病人,且治疗后高于治疗前(P<0.05)。IL-4、IL-10水平在各组标本无明显差异。结论:心肌梗死急性发作与免疫应答有关,并可能向TH2应答偏移。Objective： To investigate the pathophysiologic significance of serum level changes of some cytokines in acute myocardial infarction （AMI）. Methods： The serum levels of IFN-γ, TNF-α, TGF- β, and IL-4, IL-6, IL-10 in 27 cases of AMI and 29 healthy people （ as control） were measured with a sensitive sandwich enzyme-linked immunosorbent assay （ELISA）. Results： （ 1 ） Levels of IFN-γ were higher in control group than those in AMI group. Levels of TNF-otin AMI group were significantly higher after treatment than before （ P 〈 0. 001 ）. （ 2 ） Levels of IL-6 in AMI group were lower after treatment than before （P 〈0.01）, and were both higher than those of the controls （P 〈0.05）. TGF- β1 Levels in AMI group were lower than those of healthy control, and were higher after treatment than before the treatment. No significant difference was found among the levels of IL-4 and IL-10 in both groups. Conclusions： The acute seizure of myocardial infarction relates to immunological response, and might have a bias trend to TH2 response.

关 键 词：心肌梗死 细胞因子类 酶联免疫吸附测定 

分 类 号：R542.2[医药卫生—心血管疾病] R446.62[医药卫生—内科学]