2-苄氧基-5-氟-4-嘧啶酮-3-丁酸乙酯的合成及结构鉴定  

The Synthesis and Structure-identification of 2-Benzyloxy-5-fluoro-4-oxo-pyrimidine-3-butyric Acid Ethyl Ester

作　　者：谢珺[1] 张旭[2] 王建塔[3] 汤磊[3] 

机构地区：[1]贵阳医学院药学系有机化学教研室,贵州贵阳550004 [2]贵阳医学院药学系分析化学教研室,贵州贵阳550004 [3]贵阳医学院药学系药物化学教研室,贵州贵阳550004

出　　处：《贵阳医学院学报》2006年第4期339-341,共3页Journal of Guiyang Medical College

摘　　要：目的:合成氟尿嘧啶类衍生物合成中的关键中间体2-苄氧基-5-氟-4-嘧啶酮-3-丁酸乙酯。方法:以5-氟尿嘧啶为原料,经4步反应合成目标产物,并用红外光谱(IR)、核磁共振(1H-NMR)进行了结构确证。结果:2-苄氧基-5-氟-4-嘧啶酮和γ-溴代丁酸乙酯反应得到两个化合物。结论:通过IR谱确证一个化合物是目标物2-苄氧基-5-氟-4-嘧啶酮-3-丁酸乙酯,另一化合物是它的同分异构体。Objective： To synthesize 2-benzyloxy-5-fluoro-4-oxo-pyrimidine-3-butyric acid ethyl ester, the key intermediate in the synthesis of fluorouracil derivatives. Methods： 2-benzyloxy-5-fluoro-4- oxo-pyrimidine-3-butyric acid ethyl ester was synthesized by using 5-fluorouracil as the starting material through four steps. Its structure was identified with IR and ^1H-NMR. Results： Two compounds were obtained in the last step. Conclusions：One compound is identified as the title compound 2-benzyloxy- 5-fluoro-4-oxo-pyrimidine-3-butyric acid ethyl ester, and the other one is its formula isomer.

关 键 词：氟尿嘧啶 红外线 磁共振波谱学 光谱分析 

分 类 号：R979.1[医药卫生—药品]