抗生素及非甾体类消炎药对ⅢA型前列腺炎血清PSA及游离PSA的影响  

Effects of Antibiotic and Anti-inflammatory Treatment on Serum PSA and Free PSA Levels in Patients with Chronic Prostatitis ⅢA

作　　者：王尉[1] 胡卫列[1] 杨槐[1] 邱晓拂[1] 张长征 

机构地区：[1]广州军区广州总医院泌尿外科广州军区泌尿外科研究所,广东广州510010

出　　处：《中华男科学杂志》2006年第9期787-790,共4页National Journal of Andrology

基　　金：全军计划生育指令性课题:热带地区男性生殖健康;广东省科技计划项目(2004B30301013)

摘　　要：目的:探讨炎症性慢性骨盆疼痛综合征(ⅢA)患者经过抗生素及非甾体类消炎药治疗的血清前列腺特异性抗原(PSA)水平及游离PSA百分率(F-PSAR)的变化。方法:ⅢA型前列腺炎患者228例,应用抗生素及非甾体类消炎药治疗4周,测定患者治疗前、治疗结束后4周及8周的血PSA水平及F-PSAR,分析治疗前后血PSA水平及F-PSAR的变化。结果:在228例ⅢA型前列腺炎患者中,血PSA治疗前为(3.51±3.03)μg/L,治疗后第4周为(2.75±2.84)μg/L,较治疗前显著下降(P<0.05);而F-PSAR由治疗前0.25±0.05升至0.27±0.03。其中PSA≥4μg/L的患者占28.5%(65/228),在PSA≥4μg/L的患者中,PSA由治疗前(6.24±1.93)μg/L降至治疗结束后第4周(4.58±2.99)μg/L(P<0.05),PSA下降的幅度为(32.9±36.1)%;治疗后PSA<4μg/L患者占27.7%(18/65),F-PSAR由治疗前(16±9)%升至治疗结束后第4周(22±11)%(P<0.05),F-PSAR上升幅度为(51.4±25.8)%。上述指标在治疗后4周和治疗后8周差异无显著性(P>0.05)。结论:慢性前列腺炎亦是血PSA升高的原因之一。在明确前列腺炎的诊断后,可以给予有效的抗感染及抗炎治疗,能显著降低血PSA水平及提高F-PSAR。Objective： To investigate the effect of antibiotics and a nonsteroidal anti-inflammatory agent on the level of total prostate specific antigen （PSA） and free PSA ratio（F-PSAR） in patients with chronic prostatitis ⅢA. Methods： A total of 228 outpatients diagnosed as with chronic prostatitis ⅢA received 4-week antibiotic and anti-inflammatory treatment. The PSA level and F-PSAR were determined before and after the treatment, and the changes analyzed. Results： Significant variations were observed in the median PSA concentrations（3.51 μg/L and 2.75 μg/L） and F-PSAR （0.25% and 0.27% ） 4 weeks after the treatment. Sixy-five of the patients （28.5%） presented with serum PSA greater than 4 ng/ml, the mean PSA decreased by 32.9% , from 6.24 μg/L before the treatmnet to 4.58 μg/L 4 weeks after the treatment （ P 〈 0. 05 ）, and the serum PSA was normalized in 18 of the 65 patients （27.7%）. The median variation of F-PSAR（0. 16% and 0.22% ） was greater than that of PSA. The variation indexes obtained 4 weeks after the treatment showed no statistical difference from those observed 8 weeks after the treatment. Conclusion ： Chronic prostatitis Ilia appears to contribute to increased serum PSA levels in some men. Antibiotic and anti-inflammatory treatment could significantly reduce the PSA level and increase F-PSAR.

关 键 词：慢性前列腺炎 前列腺特异性抗原 游离前列腺特异性抗原 抗生素 

分 类 号：R697.33[医药卫生—泌尿科学]