应用人造骨(CPC)修复骨缺损33例近期随访报告  

Repair of bone defect with calcium phosphate cement-33 cases report

作　　者：魏延云[1] 黄磊[1] 李飞[1] 李博[1] 严旭[1] 袁颖[1] 邹菊培[1] 许亦冰 

机构地区：[1]解放军第455医院骨科,上海淮海西路338号200052

出　　处：《中国矫形外科杂志》2006年第17期1299-1300,共2页Orthopedic Journal of China

摘　　要：[目的]自固化磷酸钙(CPC)为非陶瓷型羟基磷灰石类人造骨材料,它解决了长期困扰骨科的骨缺损修复这一难题。[方法]选用国产CPC修复骨缺损33例,年龄7~43岁,平均23.2岁。骨缺损部位为股骨上端、肱骨上端及股骨颈部、指骨、股骨下段、胫骨上端。骨缺损范围为1 cm×0.5 cm×0.5 cm^15 cm×3 cm×2 cm。骨缺损病因为动脉瘤样骨囊肿及纤维结构不良、非骨化性纤维瘤、骨瘤及骨软骨瘤、骨巨细胞瘤及组织性黄色肉芽肿。修复方法是彻底病灶清除,石炭酸、酒精灭活瘤细胞,彻底止血,CPC填充,封闭骨窗。[结果]CPC固化时间在15~30 m in,平均20 m in。临床使用后未见明显局部和全身不良反应,3个月后逐渐出现降解。随访最长30个月,最短13个月,平均22.5个月,随访X线片示CPC与宿主骨直接愈合,接触紧密无间隙、无脱落。[结论]CPC是骨缺损修复的理想材料。[ Objective ] Autosolidifying calcium phosphate cement （CPC） is artifical bone made by hydroxyapatite, which rosolves the freatment of bone defect. [ Method ] We have recruited 33 cases of bone defects with CPC made in China. Our patient＇s ages ranged from 7 to 43 years with an average age of 23.2 years. The bone defects were located as follows ： upend of femur and humerus, femoral neck, phalanx, down-end of femur, up-end of tibia, with bone defect 0. 5 to 45 cm2 in size. The causes of the bone defect were aneurismal bone cyst and fibrous dysplasia, non-ossifying fibroma, osteoma and osteochondroma, giant cell tumor of bone and xanthogranuloma. [Result] CPC setting time： minimum 15 minutes, and maximum 30 minutes, average 20 minutes. No systemic or local adverse reaction was noted. Degeneration occurred 3 months postoperative- ly. The patients were followed up for 3 - 30 months, average 22.5 months. X-ray exam ination showed an integrity interface between CPC and bone, and no gap existed. [ Conclusion ] CPC is an ideal method to repair bone defect, and the effect is positive. Key words：

关 键 词：自固化磷酸钙 人造骨 骨缺损 修复 

分 类 号：R687[医药卫生—骨科学]