红花注射液治疗缺血性中风急性期随机对照试验的系统评价  

Systematic review of safflower injection for acute ischaemic stroke

作　　者：马丽虹[1] 李茂峰[1] 李可建[1] 迟华基[1] 孟令军[1] 

机构地区：[1]山东中医药大学,山东济南250014

出　　处：《山东中医杂志》2006年第9期590-593,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局资助课题(编号:04-05LQ03)

摘　　要：目的:系统评价红花注射液治疗缺血性中风急性期的疗效及安全性。方法:搜集红花注射液治疗缺血性中风急性期随机对照试验文献,筛选合格文献,应用Jadad评分法进行质量评价,统计方法应用异质性检验、Me-ta-分析、漏斗图分析、敏感性分析。结果:6项研究符合纳入标准,Jadad评分显示所有研究得分均为1分,属低质量文献。Meta-分析结果显示,总有效率比较的合并相对危险度(RR值)及99%的可信区间(CI值)为1.21(1.09,1.34)。结论:Meta-分析结果显示红花注射液具有改善缺血性中风急性期患者神经功能缺损状况的趋势,尚不能确定是否存在导致不良反应的危险性。Objective. To evaluate efficacy and safety of safflower injection for acute ischaemic stroke. Methods. Randomized controlled trails （RCTs） of safflower injection for acute ischaemic stroke were iden- tified, eligible studies were included, the methodological quality of inclusive trails was assessed with Jadad scale. Heterogeneity test, Meta-analysis, funnel plot analysis and sensitivity analysis were used to analyse data. Results. Six RCTs were included, with all trails of low.methodological quality. Safflower injection vs no-treatment control, Meta-analysis indicated that RR of overall effective rate was 1.21 （1.09, 1.34）. Conclusion. This systematic review showed that safflower injection is effective for acute ischaemic stroke, side-effect unclear.

关 键 词：红花注射液 缺血性中风 急性期 随机对照试验 系统评价 

分 类 号：R255.2[医药卫生—中医内科学]