MRS定量检测活体γ-氨基丁酸浓度的研究现状  

Quantitative Measurement of γ-Aminobutyric Acid Concentration in vivo by Magnetic Resonance Spectroscopy:A Review

作　　者：陈耀文[1] 沈智威[1,2] 宿吉伟 梁兵[1] 吴仁华[4] 

机构地区：[1]汕头大学工学院 [2]汕头大学附属第二医院,广东汕头515041 [3]广东公安边防深圳指挥部 [4]汕头大学附属第二医院

出　　处：《波谱学杂志》2006年第3期409-417,共9页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金资助项目(NSFC:30270379).

摘　　要：γ-氨基丁酸(GABA)是一种重要的脑代谢物,磁共振频谱(MRS)技术可以非介入检测活体脑代谢物浓度.但使用MRS定量检测活体GABA还是会遇到很多困难.随着谱编辑技术的发展和频谱分析软件的出现,已提出了很多方法用于定量检测活体GABA浓度.本文简述了GABA的理论背景,然后介绍了国内外MRS定量检测活体γ-氨基丁酸浓度的研究现状,最后分析了MRS定量检测γ-氨基丁酸浓度的方向.γ-Aminobutyric acid （GABA） is an important metabolite in the brain. Magnetic Resonance Spectroscopy （MRS） has proven to be a valuable technique for measuring cerebral metabolite concentrations non-invasively in vivo. However, reliable detection of GABA in vivo using MRS is difficult and faces various challenges. With the developments of spectral editing techniques and specialized software packages for processing MRS data, many methods have been proposed to measure GABA in vivo. In this article, the background knowledge of GABA was briefly reviewed, and the MRS techniques currently used to do quantitative measurement of GABA in vivo were reviewed. At the end, proposals of further studies were briefly mentioned.

关 键 词：MRS 定量检测 GABA 谱编辑 LCMODEL MRUI 

分 类 号：Q517[生物学—生物化学]