Relationship between Coordination Structure and Biological Activity of Copper(II) Nicotinate  

作　　者：CHEN Qiang LI Qing-Lu 

机构地区：[1]Institute of Animal Science and Technology, Agricultural and Forestry University , Fuzhou 350002, China [2]Institute of Life Science, Key Laboratory of Biological Pesticide and Chemicobiology of Education Ministry, Agricultural and Forestry University, Fuzhou 350002, China

出　　处：《Chinese Journal of Structural Chemistry》2006年第9期1141-1147,共7页结构化学（英文）

基　　金：Supported by the Natural Science Foundation of Fujian Province (B0510012) and the Science and Technology of Science Foundation of Fujian Education Department (JA04189)

摘　　要：The copper（Ⅱ） complexes of pyridine-3-carboxylic acid （nicotinic acid） and pyridine-2-carboxylic acid （isonicotinic acid） were synthesized, and their structures were characterized by elemental analysis, infrared spectrum, powder X-ray diffraction and so on. The results show that under experimental conditions, the ligands of synthesized copper nicotinate and copper isonicotinate are coordinated simultaneity with copper（Ⅱ） via the nitrogen of pyridine group and an oxygen of carboxylic acid group to form bidentate chelates. The crystal of copper nicotinate with two six-membered chelate rings belongs to monoclinic system, while that of copper isonicotinate having two five-membered chelate rings is of triclinic system. The tests show that the biological activities, such as the improvement of feed utilization, growth, anti-oxidation ability of organism and disease-resistant power, are different when copper nicotinate, copper inicotinate, copper-lysine chelate, copper-methionine chelate and copper sulphate are added in pig＇s feed, respectively. Due to its higher biological activity, less pollution and lower toxicity, copper nicotinate has wide potential applications as a feed additive.The copper（Ⅱ） complexes of pyridine-3-carboxylic acid （nicotinic acid） and pyridine-2-carboxylic acid （isonicotinic acid） were synthesized, and their structures were characterized by elemental analysis, infrared spectrum, powder X-ray diffraction and so on. The results show that under experimental conditions, the ligands of synthesized copper nicotinate and copper isonicotinate are coordinated simultaneity with copper（Ⅱ） via the nitrogen of pyridine group and an oxygen of carboxylic acid group to form bidentate chelates. The crystal of copper nicotinate with two six-membered chelate rings belongs to monoclinic system, while that of copper isonicotinate having two five-membered chelate rings is of triclinic system. The tests show that the biological activities, such as the improvement of feed utilization, growth, anti-oxidation ability of organism and disease-resistant power, are different when copper nicotinate, copper inicotinate, copper-lysine chelate, copper-methionine chelate and copper sulphate are added in pig＇s feed, respectively. Due to its higher biological activity, less pollution and lower toxicity, copper nicotinate has wide potential applications as a feed additive.

关 键 词：pyridine-3-carboxylic acid （copper nicotinate） copper pyridine-2-carboxylic acid （copper isonicotinate） copper coordination structure toxicity GROWTH-PROMOTING enzyme activity 

分 类 号：O[理学]