复方蒲公英灌肠液氯仿部位薄层色谱指纹图谱的批间比较  

TLC Fingerprints of Chloroform Extract of Compound Herba Taraxaci Enemas:Comparison between Batches

作　　者：许重远[1] 晏媛[1] 谷晓策[1] 黄劲梅[2] 张焜[3] 

机构地区：[1]南方医科大学南方医院,广州市510515 [2]广州市药品检验所,广州市510160 [3]广东工业大学,广州市510090

出　　处：《中国药房》2006年第17期1336-1337,共2页China Pharmacy

基　　金：广东省医学科学技术研究基金面上项目(A2006401)

摘　　要：目的:比较不同批次复方蒲公英灌肠液的薄层色谱指纹图谱,为建立更稳定的制剂工艺和质量标准打下基础。方法:对2批复方蒲公英灌肠液氯仿部位进行展开,运用薄层扫描仪对样品进行单波长280nm扫描,比较不同批次之间的差异。结果:该部位薄层色谱分离良好,经薄层扫描后发现2批样品有6个共有峰,2个非共有峰,并确定了部分峰的归属药材,但共有峰含量差异较大。结论:不同批次的制剂仍很难保证在成分数目和含量上的相对一致,制剂工艺以及投料标准尚待进一步优化,医院中药制剂的质量标准仍需进一步提高。OBJECTIVE： To compare TLC fingerprints between different batches of compound Herba taraxaci enemas （CHTE） ant to lay a foundation for establishing a more stable preparation technics and quality standards for CHTE. METHODS： The chloroform extract of 2 batches of CHTE were chromatographed by TLC and the samples were scanned by TLC scanner at a Single wavelength of 280nm, the difference between different batches was compared. RESULTS： The TLC of chloroform extracts was well- separated, there were 6 common peaks and 2 non- common peaks in the TLC of 2 batches of samples, with some of the peaks identified in terms of the medicinal material categories, but there was a significant difference in contents among the common peaks. CONCLUSIONS： It was hard to guarantee the relative conformity in numbers of components and the contents between different batches of preparations, the preparation technics and quality standard of raw materials remain to be further optimized and the quality standard for Chinese herb medicinal preparations in hospital should be improved further.

关 键 词：复方蒲公英灌肠液 氯仿部位 薄层色谱 指纹图谱 

分 类 号：R927.2[医药卫生—药学]