氟暴露对工人血清免疫球蛋白和微量元素的影响及“抗氟灵”的拮抗作用研究  

A study on the effects of fluoride exposure on the immunoglobines and trace elements in the workers’serums and the antagonism by“Kangfuling”

作　　者：沈凌汛[1] 刘建东[2] 陈荣安[2] 曾达兴 褚连富 

机构地区：[1]同济医科大学附属协和医院职业病科 [2]同济医科大学公共卫生学院劳动卫生教研室 [3]工业氟病防治研究协作组

出　　处：《中国工业医学杂志》1996年第6期325-327,共3页Chinese Journal of Industrial Medicine

基　　金：中国有色金属总公司"八.五"资助

摘　　要：将氟暴露工龄５年以上的３５名自愿者分成两组，其中２０人服“抗氟灵”冲剂，１５名服安慰剂；另选同样条件的非氟暴露工人１８名为对照。均不脱离生产，进行为期一个月的观察。结果表明，在氟暴露车间平均空气氟浓度为１．５ｍｇ／ｍ３环境下，工人尿氟明显增高，血清ＩｇＧ、ＩｇＡ和微量元素Ｃｕ、Ｚｎ、Ｃａ明显下降。对服“抗氟灵”冲剂和安慰剂的工人进一步观察结果表明，“抗氟灵”进入体内与氟络合形成ＢＦ－４而增加了尿氟的排出，而且有防止血清ＩｇＧ和微量元素Ｚｎ。In this study 35 workers exposed to fluoride for more than 5 years were randomly divided into two groups. 20 of them were administrated “Kangfuling”and the rest were administrated placebo;in addtion 18 non-fluoride exposure workers in the same conditions of age,working year and health as the front two groups were selected.This study was carried out for a month in the normal working conditions, The results showed that, under the condition of average fluoride concentration in the air of fluoride exposure workshop being 1.5mg/m3,the contents of fluoride in the urine of workers were increased significantly and the contents of IgG, IgA and trace elements Cu,Zn,Ca were decreased significantly, The result of further observation on the workers administrated “ Kangfuling”and placebo indicated that“Kangfuling”increased the excretion of fluoride in urine through BF4-, the complexion of fluoride with“Kangfuling”in body,and that it could also inhibit the reduction of IgG and Zn,Ca in serum by fluoride-induced.

关 键 词：氟暴露 抗氟灵 免疫球蛋白 微量元素 

分 类 号：R992[医药卫生—毒理学] R135.1[医药卫生—药学]