普罗布考抑制兔颈动脉内膜切除术后再狭窄的实验研究  

Experimental study of inhibiting restenosis by probucol after rabbit carotid endarterectomy

作　　者：梁春阳[1] 周定标[1] 余新光[1] 许百男[1] 魏少波[1] 章文斌[1] 王世波[1] 

机构地区：[1]解放军总医院神经外科,北京100853

出　　处：《中华老年心脑血管病杂志》2006年第9期636-638,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金："十五"国家科技攻关计划重大疾病防治研究项目资助课题(2001BA703B16)

摘　　要：目的观察抗氧化剂普罗布考对颈动脉内膜切除术(CEA)后早期再狭窄形成过程的影响。方法采用血管内膜气体损伤结合高脂饲料喂养的方法建立新西兰兔颈动脉粥样硬化动物模型,随机分为实验组(30只)和对照组(30只),在此动物模型基础上行CEA,实验组在术前14天开始用普罗布考(0.6 g.kg-1.d-1)胃管灌入,连续用药,运用超声、病理等方法从影像学和组织学的角度,观察其在CEA后对新内膜的作用。结果实验组术后新内膜的厚度和面积较对照组明显减小,内膜与中膜的比例显著降低,血管残腔面积增加,狭窄率明显低于对照组,双功超声及术后病理测量均证实上述结果。结论抗氧化剂普罗布考可能通过其复杂的结构和多方面的作用机制,起到抗再狭窄的作用。Objective To observe the effects of antioxidant probucol on restenosis after carotid endarterectomy （CEA）. Methods New Zealand rabbits were used to create carotid atherosclerotic stenosis （CASS）model by air-drying of intima of carotid artery and feeding high cholesterol diet. The animals were allocated randomly to experimental group（30） and control group（30） and underwent C EA. In experimental group, probucol （0.6 g·kg^-1·d^-1 ） was given by gastric gavage from 14 days before CEA to the sampling day. The effects of probucol on neointima were studied by ultrasound and pathology. Results The thickness and area of neointima and ratio of intima/media significantly decreased and the remaining areas of vessels increased in experimental group compared with those in control group, and the rate of stenosis was lower than that in control group. These results were proved by ultrasound and pathology. Conclusion Antioxidant probucol inhibits restenosis after CEA possibly by its complicated structure and various mechanisms.

关 键 词：颈动脉内膜切除术 颈动脉狭窄 普罗布可 兔 

分 类 号：R96[医药卫生—药理学]