妊娠相关蛋白A、高敏C反应蛋白在不稳定型心绞痛患者的表达及临床意义  

The Expression and Clinical Significance of Pregnancy-associated Plasma Protein-A,High-sensitivity C-Reactive Protein in the Sera of Patients with Unstable Angina Pectoris

作　　者：翁建新[1] 刘东[1] 方伟[1] 王正瑛[1] 罗建方 张敏洲[3] 

机构地区：[1]广东省深圳市宝安区西乡人民医院心内科,518102 [2]广东省人民医院心血管研究所心内科 [3]广东省中医院ICU心导管室

出　　处：《实用全科医学》2006年第6期641-642,共2页Applied Journal Of General Practice

基　　金：深圳市宝安区科技立项目(项目编号:2005182)

摘　　要：目的检测妊娠相关蛋白A(PAPP-A)和高敏C反应蛋白(hs-CRP)在不稳定型心绞痛(UAP)患者的血清表达水平。方法将患者分为三组,分别为UAP组(n=30例),稳定型心绞痛(SAP)组(n=28例),正常对照组(n=20例),全部患者均采用酶联免疫吸附法(Elisa)测定血清PAPP-A和超敏免疫透射比浊法测血浆hs-CRP的浓度。结果UAP患者,血清PAPP-A和hs-CRP水平明显高于SAP及对照组水平(P<0.01)。结论PAPP-A及hs-CRP在血清中的水平与冠心病的严重程度有密切相关,提示两者均可作为预测UAP预后的新的敏感的标志物。Objective to explore the expression of Pregnancy-associated Plasma Protein-A （PAPP-A） and high-sensitivity Creactive protein（hs-CRP） in the sera of patients with unstable angina pectoris （UAP）. Methods 78 patients with UAP were randomly divided into three groups, including unstable angina pectoris （UAP） group （ n = 30）, stable angina pectoris （SAP） group （ n = 28 ） and normal control group （ n = 20）. The serumal levels of PAPP-A and hs-CRP in 78 cases were detected respectively by enzyme-linked immunosorbent assay（ELISA） and supersensitivity immunity turbidimetry（SSIT）. Results The serumal levels of PAPP-A and hs-CRP in the patients with UAP were significantly higher than those in SAP and .Normal control group （P〈0.01）. Conclusions The serumal levels of PAPP-A and hs-CRP are positive correlation with degree of coronary heart disease. They are sensitive markers for predicting the prognostic of UAP.

关 键 词：不稳定型心绞痛(UAP) 妊娠相关蛋白A(PAPP—A) 高敏CRP(hs—CRP) 

分 类 号：R541.42[医药卫生—心血管疾病]