大黄联合山莨菪碱对多发伤家兔胃肠道黏膜屏障的保护作用研究  

Protective effect of rhubarb combined with scopolamine on gastric and gut mucosal barrier in rabbits with multiple injury

作　　者：潘永[1] 冯锦昉[1] 徐杰[1] 张斌[1] 张兴胜[1] 邓梦华[1] 林旋[1] 潘丽玲[1] 

机构地区：[1]广东省佛山市中医院ICU,528000

出　　处：《中国医药》2006年第8期462-464,共3页China Medicine

基　　金：广东省中医药管理局科研立项课题[粤中医(2002)74号]

摘　　要：目的研究大黄联合山莨菪碱对多发伤家兔胃肠道黏膜屏障的保护作用。方法24只新西兰大白兔随机分为假手术组、一般治疗组、大黄加山莨菪碱治疗组。采用生物撞击机Ⅳ(BIM-Ⅳ)造成多发伤模型,同时给予液体复苏支持。观察各时间点循环指标(平均动脉压、心率)的变化,同时测量胃肠黏膜pH值以及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等指标。结果一般治疗组和大黄组的心率及平均动脉压均呈下降趋势,而大黄加山莨菪碱组能减轻创伤后心率、平均动脉压的下降;同时大黄组对于减慢pH值的下降和动脉血乳酸值的升高,与一般治疗组比较差异有显著性;抑制IL-6、TNF-α的升高,与一般治疗组相比差异有显著性。结论大黄联合山莨菪碱对创伤家兔胃肠道黏膜屏障具有保护作用,主要与改善局部微循环,延缓乳酸的升高和pH值的降低,抑制IL-6、TNF-α细胞因子的作用有关。Objective To investigate the protective effect of rhubarb combined with scopolamine on gastric and gut mucesal barrier in rabbits with multiple injury. Methods 24 New Zealand rabbits were randomly divided into 3 groups ： sham-operated group, common therapy group （ CM group ） , rhubarb combined with scopolamine group （ RS group）, The rabbits model of multiple injury was made by Biology Impacting Machine IV （BIM-Ⅳ ）. The mean arterial pressure （ MAP ） and heart rate （ HR ） were recorded, gastreintramueosal PH （ PHi ） , IL-6, and TNF-α were measured, Results The MAP and HR were downregulated in both CM droup and RS group, and rhubarb combined with scopolamine could decrease the downtrend; the reduce of pHi ,the ascend of artery lactic acid and IL-6,and TNF-α in CM group were significantly higher than those in RS group. Conclusion Rhubarb combined with scopolamine can protect the gastric and gut mucosal barrier in rabbits with multiple injury,which may be related to the improvement of the local microcirculation and delaying of the ascend of artery lactic acid and the reduction of pHi as well as inhibiting of IL-6 and TNF-α.

关 键 词：大黄 山莨菪碱 胃肠道黏膜 

分 类 号：R28[医药卫生—中药学]