大鼠血胰屏障对加替沙星体内分布的影响  

Transference of Gatifloxacin Across the Blood-pancreas Barrier in Rats

作　　者：陈锋[1] 王燕[2] 王贵发[2] 

机构地区：[1]浙江省新华医院药剂科,杭州310014 [2]浙江省人民医院药剂科,杭州310014

出　　处：《医药导报》2006年第9期858-860,共3页Herald of Medicine

摘　　要：目的研究大鼠血胰屏障对加替沙星体内分布的影响。方法经大鼠尾静脉推注加替沙星20mg.kg-1,在规定的时间点取样,用高效液相色谱法(HPLC)测定胰腺组织和血清中药物含量。结果在大鼠血清中加替沙星浓度在5 m in时最高,为6.03μg.mL-1,胰腺组织在10 m in时最高,为18.67μg.g-1,然后持续下降;5 m in时胰组织的药物浓度开始高于血清,240 m in后两者浓度接近。血胰屏障对药物的通透率(PR)在5 m in时为1.02,然后处于上升趋势,10 m in时最高达到3.69,然后下降,240 m in后接近1。结论静脉推注加替沙星后,血胰屏障对药物具有良好的通透性,值得向临床推荐预防和治疗胰腺感染。Objective To investigate the penetration of gatifloxacin in blood-pancreatic barrier in rats. Methods Venous bolus injection of gatifloxacin （20 mg·kg^-1 body weight） was performed through caudal vein. At the given time points, the samples were picked up. The concentrations of gatifloxacin in the serum and pancreatic tissue were measured by high performance liquid chromatography. Results The peak concentration in serum was 6.03 μg·mL^-1 at 5 min, and that of the pancreatic tissue was 18.67 μg·g^-1 at 10 min. Then the concentrations decreased continously in both of them. Concentrations in pancreatic tissue was higher than those in serum at 5 min. The penetration ratio （PR） in the blood-pancreatic barrier was 1.02 at 5 min and rose to 3.69 at 10 min, then lowered down to nearly 1 at 240 min. Conclusion Due to its antimicrobial spectrum and the good penetration in the blood-pancreatic battier, gatifloxacin may be useful in preventing and treating pancreatic infection.

关 键 词：加替沙星 血胰屏障 通透率 胰腺炎 

分 类 号：R978[医药卫生—药品] R965[医药卫生—药学]