A群链球菌制剂治疗巨大海绵状血管瘤87例  

Treatment of 87 Cases of Giant Haemangioma with Group A Streptococcus Preparation(OK-432)

作　　者：王勇[1] 汤绍涛[1] 阮庆兰[1] 童强松[1] 毛永忠[1] 李时望[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院小儿外科,武汉430022

出　　处：《医药导报》2006年第9期909-910,共2页Herald of Medicine

摘　　要：目的研究A群链球菌制剂（沙培林）治疗小儿巨大海绵状血管瘤的临床疗效及其对血清肿瘤坏死因子（TNF-α）、白细胞介素（IL-6）及C反应蛋白（CRP）的影响。方法采用自身对照，给予87例巨大海绵状血管瘤患儿瘤内局部注射A群链球菌制剂溶液，2周注射1次，6周为1个疗程，治疗前后测量瘤体直径，并作血清TNF-α、IL-6及CRP检测。结果治疗后肿瘤明显缩小，血清TNF-α、IL-6及CRP水平升高，与治疗前比较，差异有极显著性（P〈0.01）；34例患儿出现发热，持续2～3d后体温降至正常，均为一过性反应。结论瘤内注射A群链球菌制剂治疗小儿巨大海绵状血管瘤疗效显著，并具有良好的安全性。Objective To study the clinical effectiveness of group A streptococcus preparation （OK-432） in the treatnent of giant haemangioma（GH） and its effects on the serum levels of TNF-α、IL-6 and C-reative protein （CRP）. Methods Eighty-seven children with GH were submitted to a self-contrast clinical investigation. OK-432（1-2KE） was injected into each GH with a course of treatment lasting 6 weeks. Before and after the treatment, the diameters of GH were measured, and the serum levels of TNF-α、IL-6 and CRP were determined. Results The diameters of GH reduced, while the serum levels of TNF-α、IL-6 and CRP increased after the treatment, the differences being very significant as compared with the values before the treatment （P 〈 0.01）. About 34 children with GH had high temperatures after the treatment, and their temperatures declined to normal after 2-3 days. All these reactions were transient. Conclusion Injecting OK-432 intratumorly is effective and safe in treating GH in children.

关 键 词：A群链球菌制剂 血管瘤 儿童 

分 类 号：R979.1[医药卫生—药品] R732.2[医药卫生—药学]