急性冠状动脉综合征患者妊娠相关血浆蛋白A浓度的变化  

The Changes and Significance of Pregnancy-Associated Plasma Protein A in Patients with Acute Coronary Syndrome

作　　者：杨智勇[1] 李晓东[1] 毛颖[1] 刘红霞[1] 

机构地区：[1]中国医科大学附属第二临床学院心内科,辽宁省沈阳市110004

出　　处：《中国动脉硬化杂志》2006年第2期156-158,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的在急性冠状动脉综合征拟探索一种早期灵敏和特异的斑块不稳定性的标志物—妊娠相关血浆蛋白A。方法在20例急性心肌梗死患者、25例不稳定型心绞痛患者、21例稳定型心绞痛患者及15例非冠心病人群中测定妊娠相关血浆蛋白A、C反应蛋白、白细胞介素6、肌酸激酶同工酶和肌钙蛋白Ⅰ。结果急性心肌梗死患者和不稳定型心绞痛患者妊娠相关血浆蛋白A的浓度显著高于稳定型心绞痛患者和对照者(P<0.01);急性心肌梗死患者和不稳定型心绞痛患者妊娠相关血浆蛋白A与C反应蛋白、白细胞介素6呈正相关,与肌酸激酶同工酶、肌钙蛋白Ⅰ无相关性。结论急性冠状动脉综合征患者妊娠相关血浆蛋白A的升高不代表心肌特异性坏死改变,而可能提示冠状动脉粥样斑块的不稳定。Aim To evaluate pregnancy-associated plasma protein A （PAPP-A） as an early sensitive and specific marker indicating the instability of atherosclerotic plaques in patients with acute coronary syndromes （ ACS ）, Methods In 20 patients with acute myocardial infarction （AMI）, 25 with unstable angina pectoris （UAP）, 21 with stable angina pectoris （SAP）, and 15 controls without coronary heart disease, the levels of PAPP-A were measured. Meanwhile, C-reactive protein （ CRP）, Interlukin-6 （IL-6）, the MB isoenzyme of creatine kinase （CK-MB） and cardian troponin ] （cTn Ⅰ） were examined. Restilts The PAPP-A, CRP and IL-6 levels were significantly higher in patients with AMI and UAP than in patients with SAP and controls （ P 〈 0.01 ）. In patients with ACS （ including AMI aand UAP）, PAPP-A correlated with levels of CRP and IL-6, but not with markers of myocardial injury CK-MB and cTn Ⅰ . Conclusions PAPP-A levels are elevated in ACS. These increased levels may reflect the instability of atheroselerotic plaques in coronary artery, not representing specific mocardial necrosis.

关 键 词：内科学 急性冠状动脉综合征患者妊娠相关血浆蛋白A浓度的变化 时间分辨光度法 急性冠状动脉综合征 妊娠相关血浆蛋白A C反应蛋白 白细胞介素6 

分 类 号：R5[医药卫生—内科学]