吸烟者血浆VitC、VitE、β－CAR、LPO和E－SOD值的检测  

The measurement of plasma vitamin C and E,β carotene,lipoperoxides contents and erythrocyte superoxide dismutase activity in healthy aged smokers

作　　者：周君富 丁德云 郭芳珍[2] 孙宁亚[2] 钱志君[2] 

机构地区：[1]浙江省药物滥用监测站 [2]浙江医科大学附属二院

出　　处：《实用老年医学》1996年第5期205-208,共4页Practical Geriatrics

基　　金：浙江省卫生厅科研基金

摘　　要：检测３８４例健康老年吸烟者和１７６例健康老年非吸烟者血浆维生素Ｃ（Ｐ－ＶｉｔＣ）、维生素Ｅ（Ｐ－ＶｉｔＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）、过氧化脂质（Ｐ－ＬＰＯ）含量和红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）活性的结果表明，与非吸烟组比较，吸烟组的Ｐ－ＶｉｔＣ、Ｐ－ＶｉｔＥ、Ｐ－β－ＣＡＲ和Ｅ－ＳＯＤ平均值显著降低（Ｐ＜０．００１），而Ｐ－ＬＰＯ平均值显著升高（Ｐ＜０．００１）；８２例６１岁男性吸烟者Ｐ－ＶｉｔＣ、Ｐ－ＶｉｔＥ、Ｐ－β－ＣＡＲ和Ｅ－ＳＯＤ均随吸烟史及吸烟量的增加而降低，Ｐ－ＬＰＯ随吸烟史及吸烟量的增加而升高，并均呈一定程度的直线相关（Ｐ＜０．０００１）。提示老年吸烟者体内的氧化和抗氧化平衡严重失调，氧自由基反应和脂质过氧化反应明显加剧。The results of measuring the plasma vitamin C(P VitC),vitamin E (P VitE),β carotene (P β CAR),lipoperoxides (P LPO)contents and erythrocyte superoxide dismutase (E SOD) activity of 384 healthy aged smokers and 176 healthy aged nonsmokers showed that the average P VitC,P VitE,P β CAR contents and E SOD activity of the smoker group were significantly lower than those of the nonsmoker group( P <0 001)and the average P LPO content of the smoker group was significantly higher than that of the healthy nonsmoker group ( P <0 001);82 smokers P VitC,P VitE,P β CAR and E SOD decreased as their smoking period and quantity increased ( P <0 001),and smokers P LPO content increased as their smoking period and quantity increased ( P <0 0001).It suggested that the balance between oxidation and antioxidation in the body of the smokers was apparently unbalanced and their oxygen free radical reaction and lipoperoxidation reaction significantly aggravated.

关 键 词：吸烟 维生素C 过氧化脂质 超氧化物歧化酶 

分 类 号：R163[医药卫生—公共卫生与预防医学]