螺内酯对大鼠肾间质纤维化的保护作用  

Protective Effect of Spironolactone on Rats with Renal Interstitial Fibrosis

作　　者：陈小珍[1] 刘杰[1] 曹志刚[1] 张子芬[1] 曹学森[1] 司钰媚[1] 林海英[2] 

机构地区：[1]河北省邯郸市第一医院肾内科,056002 [2]河北医科大学第三医院肾内科,河北省肾脏病研究中心

出　　处：《中国全科医学》2006年第17期1426-1427,共2页Chinese General Practice

摘　　要：目的观察螺内酯对单侧输尿管梗阻(UUO)大鼠的肾皮质纤溶酶原激活物抑制物-1(PAI-1)表达介导的肾间质纤维化的作用。方法UUO大鼠给予螺内酯20mg.kg-1.d-1灌胃,用RT-PCR方法检测术后7、14、21dPAI-1mRNA的表达。结果与假手术组相比,UUO组及药物治疗组的PAI-1mRNA表达水平均增高(P<0.05),但治疗组低于UUO组(P<0.05)。结论螺内酯可通过下调PAI-1减轻UUO术后肾组织间质纤维化。Objective To investigate the effect of aldosterone antagonist （spironolactone） on the expression of type 1 plasminogen activator inhibitor （PAI - 1 ） in renal interstitial fibrosis following unilateral ureteral obstruction （UUO） in rat kidney. Methods UUO group, spironolactone （20 mg·kg^-1·d^-1） was given, RT -PCR was performed to investigate the expression of PAI- 1 mRNA on the 7, 14 and 21 day in the kidney. Results In comparison with the sham group, the expression of PAI- 1 mRNA of UUO and medication groups increased significantly （ P 〈 0, 05 ）, meanwhile spironolactone could significantly decrease the expression of PAI- 1 as compared to UUO group （ P 〈 0. 05 ）. Conclusion Spironolaetone may play a protective role in renal interstitial fibrosis following UUO through the down - regulation of PAI - 1.

关 键 词：肾间质 纤溶酶原激活物抑制物-1 纤维化 螺内酯 

分 类 号：R983.1[医药卫生—药品]