糖尿病伴或不伴冠心病患者血栓前状态的研究  

Study on Prothrombotic Status in Diabetic with or without Coronary Heart Disease

作　　者：秦明照[1] 宋艾[2] 翟艳玲[2] 

机构地区：[1]首都医科大学附属北京同仁医院干部保健科,北京市100730 [2]首都医科大学附属北京同仁医院心血管中心,北京市100730

出　　处：《中国全科医学》2006年第18期1497-1499,共3页Chinese General Practice

摘　　要：目的探讨糖尿病(DM)伴或不伴冠心病(CHD)患者血栓前状态指标的改变情况。方法随机选取51例确诊为DM的患者为研究对象,依据是否伴发CHD分为DM组(A组,n=20),DM+CHD组(B组,n=31),另以20例健康志愿者作为对照组(C组);各组均测定血浆蛋白C系统血栓调节蛋白(TM)、蛋白C(PC)含量及活性、蛋白S(PS)含量,vW因子(vWF)及纤溶酶原激活物抑制物(PAI-1)的水平,并分析上述指标与心血管疾病影响因素的关系。结果A、B两组患者PC活性、vWF及PAI-1水平均较C组增高(P<0·05),但A、B两组间差别无显著性意义(P>0·05);A组PC含量较C组增高(P=0·041);3组间TM和PS含量差异差别无显著性意义(P>0·05)。结论糖尿病患者血栓前状态涉及蛋白C系统、内皮及纤溶系统异常,主要表现为PC活性、vWF及PAI-1升高。Objective To explore the prothrombotic status in diabetic with or without coronary heart disease （CHD）. Methods 51 diabetes mellitus （DM） patients were randomly divided into two groups： DM group （group A, n =20）, DM ＋ CHD group （ group B, n = 31 ）. While 20 healthy persons were controllers （ group C）. The Protein C system （ TM, the content and activity of PC, PS） , vWf and PAl - 1 were measured. The relationship was analyzed between the above markers and the cardiovascular influential factors. Results The activity of PC, and the level of vWF and PAl - 1 in group A and group B were obviously higher than those in group C （ P 〈 0. 05 ） , there was no significant difference between group A and group B （ P 〉 0.05 ）. The content of PC in group A was higher than that in group C （ P =0. 041 ）. The content of PS and TM had no obvious difference among three groups （ P 〉 0. 05 ）. Conclusion The prothrombotic status of DM patients involves the abnormality of protein C system, endothelium system and fibrinolysis system, which mainly shows the elevation of PC, vWF and PAl - 1.

关 键 词：糖尿病 蛋白C系统 VW因子 纤溶酶原激活物抑制物-1 冠心病 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]