角质层渗透性质的有限元数值模拟计算  

Numerical Simulation of the Stratum Corneum's Penetration Property Using Finite Element Method

作　　者：刘宇红[1] Dirk Feuchter Gabriel Wittum 张恩平[1] 曾衍钧[1] 

机构地区：[1]北京工业大学生物力学与医学信息研究所 [2]Technical Simulation Group of the Interdisciplinary Center for Scientific Computing of University Heidelberg,Imneuen HeimerFeld368,69120,Heidelberg,Germany

出　　处：《中国生物医学工程学报》2006年第2期219-223,共5页Chinese Journal of Biomedical Engineering

基　　金：德国DAAD奖学金

摘　　要：角质层是皮肤屏障作用的最主要部分,它决定可外界物质对皮肤的渗透情况。本研究在假设角质层细胞为一种三维的十四面体(物理学经典的Tetrakaidecahedron体)下,进行对角质层渗透性质的数值模拟工作。为此,首先完成了对角质层空间结构的网格拆分,拆分过程分两步进行:首先对角蛋白细胞的网格拆分;然后对角蛋白细胞周围的网状脂质体的网格拆分。在数值模拟过程中,则用有限元法得到方程的离散格式,用多重网格算法降低高频误差,提高计算精度。最后,给出了数值模拟结果的可视化效果图。How could the outer substance penetrate through the skin lies on the stratum corneum, because it is the main barrier in the multi-layers of the skin. In this work, supposing the keratin ceil with a special geometry as Tetrakaidecahedron, the discretization of the stratum corneum region was given at first in two steps： 1. The discretization of the keratin cell; 2. The discretization of fattiness that surrounds the keratin. Then numerical simulation was performed using finite element method and the multi-grid method. The former was to obtain the discretization of basic elements, the latter was to decrease the high frequency error. A visualization of the numerical simulation was shown in the paper.

关 键 词：角质层 Tetrakaidecahedron 网格拆分 有限元方法 

分 类 号：R318.01[医药卫生—生物医学工程]