上海市母产前发热与早期新生儿败血症临床多中心研究  

Maternal antepartum fever and early-onset bacterial sepsis in neonates in Shanghai

作　　者：王旭红[1] 沈月华[1] 黄咏梅[1] 施婴婴[1] 丁善雯[1] 刘志伟[1] 唐征[1] 黄小艺[1] 张鑫瑜[1] 周静[1] 魏晏[2] 夏璟[3] 汤国英 姚明珠 虞敏毓[6] 

机构地区：[1]中国福利会上海国际和平妇幼保健院儿科,200030 [2]上海仁济医院儿科 [3]上海第一人民医院儿科 [4]上海普陀区妇幼保健院儿科 [5]上海第一妇幼保健院儿科 [6]上海第六医院产科

出　　处：《中华围产医学杂志》2006年第4期262-265,共4页Chinese Journal of Perinatal Medicine

摘　　要：目的探讨母产前发热与早期新生儿败血症之间的关系,以降低围产儿死亡率。方法采用回顾性分析方法,对有母产前发热的新生儿103例与无产前发热的新生儿311例临床资料进行对比分析,同时分析103例有产前发热的新生儿的有关因素。结果母产前发热组较无母产前发热组在早期新生儿败血症发生率方面有极显著的差异(4.9%和0.3%,P<0.01),母产前发热≥39℃,产后连续发热数天提示新生儿发生宫内感染性败血症的可能性较高。结论对于母亲产前高热、产后又继续发热的新生儿,要注意作好母宫腔分泌物培养及新生儿血培养,完善实验室检查,密切观察临床表现,必要时予抗生素应用,积极治疗,降低围产儿死亡率。Objective To evaluate the relationship between maternal antepartum fever and early-onset neonatal bacterial sepsis. Methods A retrospective multi-centred clinical study of 404 neonates including 103 new borns with maternal antepartum fever and 311 neonates without was conducted. Results The frequency of early-onset neonatal bacterial sepsis was significantly higher in neonate with maternal antepartum fever than those without （4. 9% vs 0.3%, P=0. 001）. Both maternal antepartum temperature ≥39℃ and maternal postpartum fever lasting several days was higher suggested the possibility of neonatal sepsis. Conclusions The neonates born with high risk factor of earlyonset neonate bacterial sepsis require comprehensive lab evaluation including blood culture and uterine culture, clinical observation and aggressive treatment to decrease the mortality.

关 键 词：妊娠并发症 感染性 发热 婴儿 新生 败血病 

分 类 号：R722.1[医药卫生—儿科]