Synthesis and Characterization of Suspension Polymerized Styrene-Divinylbenzene Porous Microsphere Using as Slow-Release-Active Carrier  

用作活性物载体聚苯乙烯-二乙烯苯多孔交联微球的悬浮聚合制备及表征

作　　者：李璐 程江 文秀芳 皮丕辉 杨卓如 

机构地区：[1]School of Chemical and Energy Engineering, South China University of Technology, Guangzhou 510640, China

出　　处：《Chinese Journal of Chemical Engineering》2006年第4期471-477,共7页中国化学工程学报（英文版）

基　　金：Natural Science Foundation of Guangdong Province （No.05006556）.

摘　　要：Functional porous microspheres used for the slow release carrier of actives in cosmetics or pharmaceuticals were prepared by modified suspension polymerization of styrene （ST） with divinylbenzene （DVB） in the presence of toluene, cyclohexanol and heptane as porogenic diluents. The use of ultrasonic dispersion decreases the beads＇ size and improves the uniformity. The effects of the porogen mixture, DVB content and solvent extraction on the surface performance of the synthesized beads were studied. The microspheres were characterized by scanning electron microscopy （SEM） and BET surface area determination. It was found that a great proportion of the non-solvating porogen increases the pore diameter and the specific surface area. High DVB concentration also results in the great specific surface area and porosity. When the ratio of toluene/cyclohexanol is 1：2, DVB content is at the range of 40%-60% and methylene chloride was used as extractant, the beads with good spherical shape and pore size were obtained. The prepared porous microspheres were applied as active carriers and showed satisfactory slow release effect. Over 10h constantly sustained release was observed in vitro releasing test for hydroquinone-loaded microspheres. Great surface area promoted high concentration of released hydroquinone.

关 键 词：porous microsphere suspension polymerization ultrasonic dispersion slow release 

分 类 号：O632.13[理学—高分子化学]