紫外双波长分光光度法考察注射用加替沙星在替硝唑葡萄糖注射液中配伍的稳定性  

Compatible stability of gatifloxacin for injection in tinidazole glucose injection by dual ultraviolet wavelength spectrophotometry

作　　者：杨继章[1] 刘瑞琴[1] 杨树民[1] 

机构地区：[1]河北医科大学第一医院,河北石家庄050031

出　　处：《中国医院药学杂志》2006年第9期1061-1062,共2页Chinese Journal of Hospital Pharmacy

基　　金：河北省卫生厅科研课题(编号:04177)

摘　　要：目的:考察注射用加替沙星与替硝唑葡萄糖注射液配伍的稳定性。方法:在室温(20℃),观察8h内加替沙星(2g.L-1)与替硝唑(4g.L-1)配伍液的外观、pH值及紫外光谱的变化,用紫外双波长分光光度法测定两种药物的含量。结果:两药配伍后,8h内的含量、pH值及外观均无明显变化。结论:加替沙星与替硝唑葡萄糖注射液配伍稳定。OBJECTIVE To study the compatibility of gatifloxacin for injection in tinidazole glucose injection. METHODS At room temperature （20℃ ）for 8 hours,a dual ultraviolet spectrophotometry was designed to study on the change of content after the combination of gatifloxacin（2 g·L^-1 ） and tinidazole（4 g·L^-1 ） ,and the change of the liquid appearance and its pH were observed. RESULTS No significant change was found in 8 hours. CONCLUSION Gatifloxacin for injection can be mixed with tinidazole glucose injection.

关 键 词：加替沙星 替硝唑 配伍 稳定性 紫外分光光度法 

分 类 号：R969.2[医药卫生—药理学]