活络健骨胶囊对佐剂性关节炎大鼠的作用及机制研究  

Study on Effects and Mechanism of Huoluojiangu Capsule on Adjuvant Arthritis Rats

作　　者：周家茂[1] 严奉祥[2] 全建设[1] 周继[1] 李葵香[1] 余平[1] 周小兵[2] 谢蓝[1] 陈羿汐[1] 聂兰秀[1] 殷世柱[1] 

机构地区：[1]湖南环境生物学院医学部,湖南衡阳421001 [2]南华大学药理研究所,湖南衡阳421001

出　　处：《中国中医药信息杂志》2006年第9期34-36,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖南省教育厅资助课题(05D031)

摘　　要：目的探讨活络健骨胶囊对弗氏完全佐剂性关节炎(AdjuvantArthritis,AA)型大鼠的作用及机制。方法采用弗氏完全佐剂(FCA)造模,观测该药对AA鼠关节肿胀度、胸腺、脾重的影响,并测定血清过氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)活力及一氧化氮(NO)、丙二醛(MDA)的含量。结果活络健骨胶囊能减轻AA鼠关节肿胀度及脾的重量,抑制AA鼠体重的减轻,使AA鼠体内降低的SOD、GSH-Px水平升高,并降低血清中病理性增高的NO及MDA的浓度。结论活络健骨胶囊具有良好的抗自由基、抗炎等作用。Objective To study the effects and possible mechanism of Huoluo Jiangu Capsule （HJC） on adjuvant arthritis rats. Methods The arthritic model of rats induced by Freund＇s complete adjuvant was used in experiment. The effect of HJC on swelling degree of feet, weight of thymuse and spleen of AA rats were observed. The serum activity of SOD, GSH-Px and content of NO, MDA were determined. Results HJC can relieve swelling degree of feet and weight of spleen of AA rats, increase serum SOD, GSH-Px and decrease serum NO, MDA of AA rats. Conclusion HJC has good effet of cleaning up the oxygen free radicals and anti-inflammatory.

关 键 词：活络健骨胶囊 佐剂性关节炎 抗自由基 抗炎 

分 类 号：R285.5[医药卫生—中药学]